摘要
目的:观察雷贝拉唑三联疗法根除幽门螺杆菌(H.pylori,Hp)和治疗十二指肠球部溃疡的1周与2周疗效对比。方法:72例经胃镜诊断为十二指肠球部溃疡活动期并Hp阳性的患者随机分成1周疗法组(A组)和2周疗法组(B组),A、B两组用药均为雷贝拉唑10 mg,每日2次;阿莫西林1.0 g,每日2次;克拉霉素500 mg,每日2次。A组抗生素(阿莫西林和克拉霉素)只用1周,B组用2周,雷贝拉唑均用2周。停药4周之后复查胃镜观察溃疡愈合及Hp根除。结果:溃疡愈合率A、B两组分别为80.5%(29/36)和86.1%(31/36);Hp根除率为91.6%(33/36)和94.4%(34/36);A、B两组之间比较,各项结果均无明显差异(P>0.05)。结论:雷贝拉唑三联疗法对根除Hp及治疗十二指肠球部溃疡的疗效及安全性1周与2周比较无差异性。但1周疗法经济,不良反应很少,且患者耐受性好。
Objective： To observe and compare the curative effect of rabeprasole, clarithromycin and amoxiciUin triple therapy of one week and two weeks for duodenal ulcer with Helicobacter pylori （Hp）infection. Methods：72 cases of duodenal ulcer patients with Hp infection were randomly divided into two groups,Group A （n=36）was administrated with rabeprazole 10 mg for two weeks,clarithromycin 500 mg and amoxieillin 1 000 mg for 7 days,bid.per oral,while Group B（n=36）with rabeprasole 10 mg,elarithromycin 500 mg and amoxicillin Ⅰ 000 mg all for two weeks ,bid,per oral.Hp was tested after by gastric endoscopy on the sixth weekends. Results：The Hp eradication rate, active ulcer healing rate was 91.6%（33/36）and 80.5%（29/36）in group A and 94.4%（34/36）and 86.1%（31/36）in group B.There was no statistical difference between the two groups （P〉0.05）. Conclusions：The difference of curative effect of Rabeprazole-based triple therapy for duodenal ulcer with positive Hp between one week with two weeks was not notable.But one week treatment was more economical and with less side effects when compared with two weeks treatment.
出处
《赣南医学院学报》
2010年第2期227-228,共2页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
