摘要
目的探讨矽肺与ＮＯ及氧化和脂质过氧化的关系。方法检测７３例矽肺患者和６０例健康对照者的血浆ＮＯ、ＶｉｔＣ、ＶｉｔＥ、β胡萝卜素（βＣＡＲ）、过氧化脂质（ＬＰＯ）含量及红细胞超氧化物歧化酶（ＳＯＤ）、过氧化氢酶（ＣＡＴ）、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）活力和ＬＰＯ含量。结果与对照组比较，矽肺组的血浆ＶｉｔＣ、ＶｉｔＥ、βＣＡＲ含量及红细胞ＳＯＤ、ＣＡＴ、ＧＳＨＰｘ活力显著降低，血浆ＮＯ、ＬＰＯ含量及红细胞ＬＰＯ含量显著升高（Ｐ＜０．０５或Ｐ＜０．０１）；各检测值与病程均有相关；血浆ＮＯ、ＶｉｔＥ含量及红细胞ＳＯＤ活力、ＬＰＯ含量与病程相关最密切。结论矽肺患者体内的ＮＯ代谢异常，氧化和脂质过氧化反应病理性加剧。
Objective To study the correlation between silicosis and nitric oxide,oxidation and lipoperoxidation. Methods The nitric oxide(NO),Vit C,Vit E,beta carotene(β CAR) and lipoperoxides(LPO) contents in plasma and superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH Px) activities,LPO content in erythrocyte of 73 silicosis patients and 60 healthy subjects were measured. Results Compared with the control group,the average contents of Vit C,Vit E, β CAR in plasma and the average activities of SOD,CAT,GSH Px in erythrocyte of the patient group significantly lowered,the average contents of NO,LPO in plasma and LPO in erythrocyte significantly increased ( P < 0.05 or P <0.01).The linear regression and correlation showed that there were linear correlations between all indexes and silicosis courses.The stepwise regression showed that the patients condition correlated most closely to NO,Vit E contents in plasma and SOD activity,LPO content in erythrocyte. Conclusion The metabolism of nitric oxide in silicosis patients was abnormal,and oxidation and lipoperoxidation reaction in silicosis ptients were pathologically exacerbated.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1999年第1期11-13,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
矽肺
NO
氧化
脂质过氧化
Silicosis Nitric oxide Oxidation Lipoperoxidation
