摘要
目的回顾分析大于3cm直径脑胶质瘤伽玛刀分次治疗(FSRT)的疗效,评价其临床应用价值。方法搜集2007年3月至2009年3月采用FSRT的直径>3cm脑胶质瘤患者58例,其中男33例,女25例,年龄6～84岁(中位值49岁)。首次应用伽玛刀治疗24例,术后和/或放疗后复发34例。肿瘤直径3.1～7.4 cm(中位值4.1 cm),计划靶体积2.7～103.8cm3(中位值16.7cm3),FSRT总剂量21～36Gy(中位值28Gy),分4～10次(中位值7次)。结果所有病人随访3～6个月,随访率100%。局部控制率CR5.17%,PR18.97%,SD56.90%,PD15.52%,总有效率为81.03%。结论FSRT能有效控制大于3cm直径脑胶质瘤并改善患者生活质量,安全,副反应小。
Objective To assess the feasibility and the short-term effect of fractionated stereotactic radiation therapy（FSRT） with Super-Gamma-knife for brain glioma more than 3cm in diameter.Methods From march 2007 to march 2009,58 patients（34 male and 13 female） with brain glioma larger than 3cm were treated using FSRT with Super-Gamma-knife.The median age was 49（range,6～84） years old.There were 24 newly diagnosed patients and 34 recurrent patients.The largest diameter of tumors was 3.1～7.4 cm（median,4.1 cm）.Planning target volume were 2.7～103.8cm3（median,16.7cm3）.The median dose of FSRT was 28（range,21～36） Gy in 7（range,4～10） fractions.Results All patients followed up clinically for 3～6 months,In 58 patients with gliomas in brain,the tumor disappeared in 3（5.17%）,reduced in 11（18.97%）,unchanged in 33（56.90%）,and increased in 9（15.52%） with a response rate of 81.03%.Conclusion FSRT is definitive and safe with mild side effect for selected patients with gliomas larger than 3 cm.
出处
《立体定向和功能性神经外科杂志》
2010年第2期100-102,共3页
Chinese Journal of Stereotactic and Functional Neurosurgery
