摘要
目的了解某省各市、县疾病预防控制中心2007-2008年分离的8株脑膜炎奈瑟菌的病原学特征及药物敏感性。方法经培养及生化鉴定后,对菌株进行血清学及聚合酶链反应(PCR)鉴定分群,最后采用最低抑菌浓度(MIC)琼脂稀释法进行药敏试验。结果 8株脑膜炎奈瑟菌中有5株C群、1株B群、1株Y群及1株不可分群菌株。所有菌株对青霉素、氨苄西林、米诺环素、头孢曲松、头孢噻肟、美罗培南、利福平敏感,对复方磺胺甲(口恶)唑则全部耐药,对环丙沙星和左氧氟沙星各有4株耐药,对氯霉素和阿奇霉素各有1株耐药。结论 8株脑膜炎奈瑟菌的流行株中以C群为主;青霉素、头孢曲松、头孢噻肟、美罗培南等可作为治疗流行性脑脊髓膜炎的一线药物,脑膜炎奈瑟菌对喹诺酮类及大环内酯类抗生素的耐药现象需引起重视。
Objective To understand the pathogenic characteristics and drug sensitivity of 8 strains of Neisseria rneningitidis isolated in Hunan province between 2007--2008. Methods Neisseria meningitidis strains were identi- fied and clustered by serology and PCR test, drug sensitivity test was carried by minimum inhibitory concentration （MIC） agar dilution method. Results Among 8 strains of Neisseria meningitidis, 5 strains were in serogroup C, 1 in serogroup B, I in serogroup Y and 1 was unidentified. All 8 strains were sensitive to penicillin, ampicillin, minocycline, ceftriaxone, cefotaxime, meropenem, rifampicin, but resistant to sulfamethoxazole/trimethoprim, 4 strains were resistant to ciprofloxacin and levofloxacin respectively, and 1 strain was resistant to chloramphenicol and azithromycin respectively. Conclusion Eight epidemic strains of Neisseria meningitidis are mainly in serogroup C; penicillin, ceftriaxone, cefotaxime and meropenem should be used as the first-line drugs for the treatment of epidemic cerebrospinal meningitis, the resistance to quinolones and macrolides should be paid attention.
出处
《中国感染控制杂志》
CAS
2010年第3期173-175,共3页
Chinese Journal of Infection Control
关键词
脑膜炎奈瑟菌
流行性脑脊髓膜炎
血清学
聚合酶链反应
抗菌药物
微生物敏感性试验
Neisseria meningitidis
epidemic cerehrospinal meningitis
serology
polymerase chain reaction
anti microbial agents
antimicrobial susceptibility test
