摘要
为了探讨游离前列腺特异抗原（ｆＰＳＡ）与总前列腺特异抗原（ｔＰＳＡ）比率对前列腺癌的诊断价值，采用酶联免疫方法分别测定４１例前列腺癌病人，３６例前列腺增生（ＢＰＨ）病人血清ｔＰＳＡ、ｆＰＳＡ，并计算出ｆＰＳＡ／ｔＰＳＡ比率。ｔＰＳＡ界限值为４μｇ／Ｌ时，敏感度，特异度，准确度分别为８２．９％，６０．０％，７２．４％；ｆＰＳＡ／ｔＰＳＡ界限值定为１７．０％时，敏感度，特异度，准确度分别为８７．８％，９３．０％，８４．２％。结果表明：ｆＰＳＡ／ｔＰＳＡ在保持敏感度的同时，可显著地提高特异度。
To study the clinical value of free to total prostate specific antigen ratio in prostate carcinoma,total prostate specific antigen(t PSA) and free prostate specific antigen(f PSA) were measured in 41 cases of prostate cancer and in 35 benign prostatic hyperplasia(BPH),and f PSA/t PSA ratio was calculated.When the cutoff value of t PSA was set at 4.0 μg/L,the sensitivity、specificity and accuracy was 82.9%、60.0% and 72.4%,respectively.When cutoff value of f PSA/t PSA was set at 17.0%,the sensitivity、specificity and accuracy was 87.8%、93.0 and 84.2%,respectively.These findings suggest that f PSA/t PSA determinations improve the specificity of t PSA test without impairing the sensitivity in diagnosis of prostate cancer,may be more useful as prostate cancer marker.
出处
《实用癌症杂志》
1999年第1期51-52,共2页
The Practical Journal of Cancer
关键词
前列腺癌
T-PSA
F-PSA
诊断
Prostate carcinoma Total prostate specific antigen Free prostate specific antigen
