摘要
目的:评价唑来膦酸注射液治疗肿瘤骨转移疼痛的疗效及安全性。方法:将80例因恶性肿瘤骨转移引起中度以上疼痛患者随机分为两组,研究组(45例)予唑来膦酸注射液4mg溶于100ml生理盐水中静脉滴注15min。对照组(35例)予帕米膦酸二钠注射液60mg溶于500ml生理盐水中静脉滴注4h。研究期为14d。结果:两组在治疗后第14d的疼痛评分唑来膦酸优于帕米膦酸二钠(3.63vs.4.95,P=0.02)。疼痛完全缓解率、部分缓解率及总疗效率两组基本相似。在达到完全缓解时间上唑来膦酸比帕米膦酸二钠要短,在达到PR时间上唑来膦酸注射液与帕米膦酸二钠注射液相似。结论:唑来膦酸相对于帕米膦酸二钠给药时间短、给药剂量小、起效快,并具有良好的耐受性和安全性。
Objective：To evaluate the efficacy and safety of zoledronic acid injection to relieve pain due to osseous metastasis, nethods：A total of 80 patients with osseous metastasis were randomized to infuse intravenously either zoledronic acid injection 4 mg（ treatment group） for 15 rain or pamidronate injection 60rag （control group） for 4 h. Results ： NRS of treatment group was lower, the time reaching to CR of treatment group was shorter （P 〈 0.05 ）, CR, PR and RR of two groups were same. Conclusion：The injective time of zoledronic acid injection is shorter, dose is smaller, effect is faster, and has satisfactory toleration and safety.
出处
《现代肿瘤医学》
CAS
2010年第6期1194-1196,共3页
Journal of Modern Oncology
