摘要
目的本课题采用经颅磁刺激运动诱发电位(motor evoked potential,MEP)的方法 ,了解人尿激肽原酶对急性脑梗死患者运动功能恢复的影响。方法 64例急性脑梗塞患者,随机分为试验组(34例)及对照组(30例),在起病72h之内,试验组给予人尿激肽原酶(0.15PNA单位)静脉滴入,在使用药物治疗(14±3)d前后,进行经颅磁刺激运动诱发电位检查,对比观察两组患者治疗前后患侧中枢传导时间(central motor conduction time,CM-CT)及皮层运动诱发电位(motor evoked potential,MEP)波幅变化。结果治疗前,两组患者皮层MEP引出率、波幅及CMCT均无明显差异(P>0.05)。治疗后,试验组皮层MEP引出率、波幅与对照组比较仍无明显差异(P>0.05);试验组下肢皮层MEP引出率的增高程度(14.7%)明显高于对照组(6.7%)P<0.05);试验组上肢CMCT(7.6±2.28)ms较对照组(9.0±2.80)ms明显缩短(P<0.05);试验组下肢MEP波幅[2.5(1.3,5.7)]mv较对照组下肢[1.9(0.7,5.3)]mv明显增高(P<0.05)。结论人尿激肽原酶对急性脑梗死患者中枢运动传导的恢复有一定促进作用。
Objective To observe the effects of Kallidinogenase on motor evoked potential in patients of acute cer- ebral infraction. Methods Sixty-four patients were randomly divided into Kallidinogenase group （ n = 34 ） and control group （n = 30）. Patients in Kallidinogenase group received basic therapy as well as Kallidinogenase（0. 15 PNA unit） intravenous drip once everyday for （14± 3 ） d, while those in control group, only the basic therapy has been received. The transeranial magnetic motor evoked potential was recorded before the first and within 1 d after the last Kallidinogenase injection. Results The differences of M wave appearance, the wave amplitude and the central motor conduction time （CMCT） both in upper and lower limb between two groups were insignificant at the first recording（P 〉 0. 05）. After （ 14± 3） d of treatment, the upper limb CMCT was significantly reduced from （ 9. 0 ± 2.80 ） ins in control group to （ 7.6 ± 2. 28 ） ms in Kallidinogenase group（ P 〈 0. 05 ）. In the second recording, the lower limb wave amplitude was significantly increased from [ 1.9 （0. 7, 5.3 ） ] nw in control group to [ 2. 5 （ 1.3,5.7 ） ] mv in Kallidinogenase group（P 〈 0. 05）. The difference of M wave appear- ance, CMCT and wave amplitude in other limbs was insignificant between two groups in the second recording（P 〉 0. 05 ）. Conclusions We concluded that intravenous injection of Kallidinogenase may have some part in improving post stroke mo- tor recovery.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2010年第5期301-304,共4页
Chinese Journal of Nervous and Mental Diseases
关键词
人尿激肽原酶
急性脑梗死
运动诱发电位
Urinary kallidinogenase Acute cerebral infarction Motor evoked potential
