摘要
目的 比较奥美拉唑与复方铝酸铋颗粒预防急性冠脉综合征后上消化道出血的疗效.方法 将2006年～2008年住院的急性冠脉综合征患者196例纳入本组研究,其中男131例,女65例,年龄47～85岁,平均（73±12）岁,随机分为奥美拉唑组（n=115）和复方铝酸铋颗粒组（n=81）.急性冠脉综合征常规治疗的方法 相同.观察两组并发上消化道出血的发生率.结果 两组急性冠脉综合征后上消化道出血的发生率分别为：奥美拉唑组5.2%,复方铝酸铋颗粒组11.1%.两组比较差异无统计学意义（P＞0.05）.结论 急性冠脉综合征后发生上消化道出血可能与病情的严重程度和应用非甾体类抗炎药物引起胃黏膜损伤有关;急性冠脉综合征后应用胃黏膜保护剂预防上消化道出血与应用质子泵抑制剂预防有同等重要意义.
Objective To study the prevention of upper gastrointestinal bleeding after acute coronary syndrome by omeprazole and com- pound bismuth aluminate （CBA）. Methods A total of 196 in patients with acute coronary syndrome from the year of 2006 - 2008 were enrolled in the study. The patients were divided into omeprazole group （ n = I 15 ） and CBA group （ n = 81 ）. Besides, all the patients were treaded with rou- tine therapy. The morbidity of upper gastrointestinal bleeding after acute coronary syndrome was observed and recorded. Results The morbidity of upper gastrointestinal bleeding after acute coronary syndrome was 5.2% in the omeprazole group and 11.1% in the CBA group,respectively. The diferenee between the two groups was not significant（ P 〉 0. 05 ）. Conclusion The morbidity of upper gastrointestinal bleeding after acute coronary syndrome may be relative to the serious condition and the application of non - steroid anti - inflammatory drugs. It is emphasized that the proton pump inhibitor is of importance equal to CBA for the prevention of upper gastrointestinal bleeding after acute coronary syndrome.
出处
《中外医学研究》
2009年第14期10-11,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
急性冠脉综合征
上消化道出血
质子泵抑制剂
黏膜保护剥
Acute coronary syndrome
Upper gastrointestinal bleeding
Proton pump inhibitor
Compound bismuth aluminate
