摘要
目的探索经股动静脉体外循环能否有效提高心脏骤停犬的循环复苏率，缩短自主循环恢复时间及保持复苏后循环平稳。方法１６只犬随机分２组，用窒息方法造成动物心脏骤停，１０分钟后开始复苏。Ａ组用常规复苏技术，即人工呼吸、胸外心脏按压、静注肾上腺素。Ｂ组在Ａ组基础上加用经股动静脉闭胸式体外循环。观察动物循环复苏情况。结果Ａ组仅１只犬在复苏后１４分钟恢复自主循环（１／８）。Ｂ组８只犬全部复苏成功（８／８），自主循环恢复时间４０８±２３分钟。Ｂ组复苏时心脏灌注压明显高于Ａ组（Ｐ＜００１）。辅助循环５～１０分钟后停止，自主循环能保持相对平稳。结论闭胸式体外循环可有效地提高实验犬的心脏灌注压及循环复苏成功率。
Objective To determine the effect of extracorporeal circulation (ECC) through the femoral vein and artery on cardiac resuscitation after cardiac arrest. Methods Cardiac arrest was induced by asphyxiation in 16 mongreal dogs which were randomized divided into 2 groups. Group A(n=8) received standard cardiopulmonary resuscitatoon(CPR) advanced life support(ALS) 10 minutes after cardiac arrest. And group B(n=8) received ECC at an average flow rate 90 ml·kg 1 ·min 1 with standard CPR ALS 10 minutes after cardiac arrest. Hemodynamic parameters were monitored during CPR and until 3hrs after restoration of spontaneous circulation. Results 8 of 8 ECC dogs in group B, spontaneous citculation was restablished after an average interval 4 08+2 3min compared with only 1 dog was resuscitation with CPR ALS alone in group A 14 minutes after CPR P <0 05). Coronary perfusion pressure increased significantly in group B when compared with group A(8 30+2 35kPa vs 3 27+2 12kPa, ( P <0 01). All animals were alive in 3hrs after resuscitation and with stable circulation. Conclusion It is concluded that a short period of ECC after cardiac arrest can yield higher coronary perfusion pressure than reperfusion with CPR ALS and restore stable spontaneous circulation. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第1期16-17,共2页
Chinese Journal of Critical Care Medicine
关键词
体外循环
心肺复苏
股动静脉
犬
Extracorporeal circulation Cardiopulmonary resuscitation
