摘要
目的探讨支气管肺发育不良(BPD)肺功能变化及临床意义。方法 BPD早产儿为观察组,胎龄、体重与观察组无差异、无心肺疾患的非BPD早产儿为对照组,分别进行肺功能检测,比较两组在2月龄和8月龄时潮气呼吸流速容量环形态及主要参数变化。结果 2月龄和8月龄时观察组与对照组比较,潮气流速容量环均变窄,呼气曲线升枝陡峭,呼气高峰提前,降枝呈近似直线或波谷样凹陷。观察组呼吸频率和潮气呼气峰流速增加,潮气量、呼气达峰时间和呼气达峰容积减少,差异有统计学意义(P均<0.05),剩余25%潮气量时呼气流速/呼气峰流速观察组低于对照组(P<0.01),潮气吸气和呼气中期流速两组差异无统计学意义。结论 BPD导致的婴幼儿肺功能损害主要表现为小气道阻塞性改变,潮气呼吸流速容量环可作为评价BPD婴儿肺功能损害的客观依据。
Objective To observe pulmonary function changes in infants with bronchopulmonary dysplasia and to discuss their clinical significance. Methods Twenty-eight infants with bronchopulmonary dysplasia in premature were enrolled in the study, twenty-eight infants with lung-free disease as control. The two groups had no differences in birth weight and gestational ages. Results For the infants with BPD at 2 months and 8 months of age, tidal breathing flow-volume loops （TBFVLs） became narrow, the rising limbs became more cliffy and the declined limbs became linear-like or trough- like concave. The respiratory rate and peak tital expiratory flow （PTEF） were significantly increased （P 〈 0. 05 ）, While tidal volume, the exhaled time at PTEF and the exhaled volume at PTEF were significantly decreased （P 〈0.05） compared to controls. The ratio of TEF 25% to FFEF, which is the best response to a sensitive parameter of small airway function, significantly decreased to controls （P 〈 0. 01 ）. But mid-inspiratory flow and mid-exspiratory flow showed no significant difference. Conclusion Bronchopulmonary dysplasia results in impaired pulmonary function, especially for obstruction in small airway. The results suggest that TBFVLs can be used as the important criteria for damage of lung function of BPD.
出处
《中国新生儿科杂志》
CAS
2010年第4期212-215,共4页
Chinese Journal of Neonatology
关键词
支气管肺发育不良
潮气呼吸流速容量环
呼吸功能试验
婴儿
早产
Bronchopulmonary dysplasia
Tidal breathing flow-volume loops
Pulmonary function tests
Infant, premeture
