摘要
观察沙鼠脑缺血再灌注后纳洛酮对海马神经元c－fos蛋白表达及神经元形态改变的影响。方法采用沙鼠急性全脑缺血模型，用免疫组织化学及组织化学方法观察海马c－fos蛋白表达及细胞形态改变。结果纳洛酮能明显加强急性全脑缺血沙鼠海马各区c－fos蛋白的表达，CA1区尤为明显。同时纳洛酮能明显改善缺血后CA1区神经元细胞的变性坏死。结论纳洛酮对缺血后海马神经元细胞的保护作用可能与加强c－fos蛋白的表达有关。
The aim of present study is to investegate the effect of naloxone on the c－fos protein expression in hippocampus neuron after transient global cerebral ischaemia． Methods The immunohistochemical and histochemical methods were used to evaluate the changes of the c－fos protein expression and cell structure in hippocampus． Results Naloxone had marked effect on the induction of c－fos protein expression and protected cell structure in hippocampus following transient global cerebral ischaemia in gerbils． Conclusion The protective effect of naloxone on hippocampal neurons might be related with increasing c-fos protein expression after cerebral ischaemia and re－perfusion．
出处
《中国神经免疫学和神经病学杂志》
CAS
1999年第1期12-14,共3页
Chinese Journal of Neuroimmunology and Neurology
