摘要
吲哚胺2,3双加氧酶（IDO）是色氨酸沿犬尿酸途径分解代谢的限速酶,其高表达是导致肿瘤免疫耐受的原因之一,直接影响树突状细胞（DC）疫苗的肿瘤治疗效果.脂多糖和细胞凶子等物质可调节IDO的表达.IDO通过3种机制参与肿瘤局部免疫耐受.对IDO的这种免疫调节机制的深入研究将在胆囊癌等肿瘤治疗方面具有重大意义.
Indoleamine 2,3-dioxygenase（IDO）is the rate-limiting enzyme in the catabolism of trypto-phan along the kynurenine pathway.Over expression of IDO is one of the reasons which are responsible for immune tolerance of tumor.IDO also affects the effects of the vaccine of the dendritic cell in the tumor therapy.Lipopolysaccharide（LPS）,cytokines and so on can regulate the expression of IDO via different regulating mechanisms.IDO participates in the local immune tolerance of tumor by three kinds of mechanisms.Further research on this immunological regulatory mechanism will be significant for tumor immunotherapy.
出处
《国际外科学杂志》
2010年第7期476-479,共4页
International Journal of Surgery
基金
国家自然科学基金资助项目（No.30840096）
关键词
吲哚胺2
3双加氧酶
免疫耐受
树突状细胞
胆囊癌
色氨酸
Indoleamine 2,3-dioxygenase
Immune tolerance
Dendritic cell
Gallbladder neoplasms
Tryptophan
