摘要
目的观察石油化工企业大气污染对企业职工α1-抗胰蛋白酶(α1-AT)浓度的影响。方法将石化体检者按工作年限分组,Ⅰ组(<10年)291例,年龄22～35岁,Ⅱ组(10～20年)634例,年龄33～45岁,Ⅲ组(>20年)427例,年龄44～55岁。正常对照组根据石化体检者的分组情况按年龄<35岁、35～45岁、>40岁分组,所有血清样本在全自动生化分析仪上检测α1-AT含量,观察不同组间结果的差异。结果Ⅰ组中石化体检者α1-AT结果为2.58±0.38 g/L,P>0.05,与对照组差异无统计学意义,Ⅱ组和Ⅲ组α1-AT结果分别为2.02±0.43 g/L和1.72±0.41 g/L,P<0.05,与对照组差异有统计学意义。同时,石化体检者不同工作年限Ⅰ、Ⅱ、Ⅲ组间血清α1-AT结果差异有统计学意义,P<0.05。而正常对照不同年龄组α1-AT结果间差异无统计学意义,P>0.05。结论石油化工厂在进行石油冶炼过程中排放的二氧化氮、烯烃、链烷、醇、羰基等有害物质,对人体的α1-AT含量产生了一定的影响,石油化工企业在积极治理厂区大气环境污染的同时,对职工定期监测α1-AT含量,及时采取一定的治疗手段,对降低肺部疾病的发病率有着重要意义。
Objective To observe the effect of atmospheric pollution on workers＇α1-antitrypsin concentrationb in petrochemical enterprises.Methods During health examination,the workers were indivded into 3 groups according tO the length of job experience.Ⅰ group（〈10 years）included 291 cases,aged 22-35 years old,Ⅱ group（10-20 years）included 634 cases,aged 33-45 years old,and Ⅲgroup（〉20 years）included 427 cases,aged 44-55 years old.The normal control were individed int different group according to the status of petrochemical workers.,all the serum samples were detected on automatic biochemical analyzer,α1-antitrypsin levels were analyzed between the different groups.Results In group Ⅰ,the α1-AT concentration was 2.58±0.38 g/L（P〉0.05）without significant difference compared with control.In group Ⅱ and Ⅲ,the concentration α1-AT were 2.02±0.43 g/L and 1.72±0.41 g/L respectively with significant differences compared with control.And the significant difference existed among the three groups of petrochemical workers..But the sigficant difference did not exist between different group of control people.Conclusion During the process of oil refining,the plants exhausted the polluted gas of nitrogen dioxide,olefins,alkanes,alcohols,carbonyl and other harmful substances,it influenced theα-AT levels of body.It is a good suggestion to decreas the petrochemical pollution,and to monitor the serum concentration of α-AT content among petrochemical workers,it might to reduce the incidence of lung disease of great significance.
出处
《国际检验医学杂志》
CAS
2010年第6期563-564,共2页
International Journal of Laboratory Medicine
关键词
Α1-抗胰蛋白酶
环境污染
实验室技术和方法
α1-antitrypsin antitrypain
environmental pollution
Laboratory Techniques and Procedures
