摘要
目的比较湿涂片法和革兰染色法在妊娠期无症状细菌性阴道病诊断中的应用价值。方法普查本院2006年9月至2009年1月期间妇产科门诊参加孕前检查无症状妊娠期患者。将临床常用诊断法(阴道分泌物pH值、吹气试验和线索细胞等3项标准中有2项为阳性)与革兰染色诊断法(Nugent标准下细菌性阴道病为7～10分)相比较。结果受试者的群体特征包括:入选孕妇平均为(27.3±6.6)周龄,其中26例为未产妇,受试时的平均孕龄为(15.6±7.6)周。其中27%(18/67)用革兰染色法确诊为细菌性阴道病(bacterial vaginosis,BV)。使用革兰染色法作为诊断细菌性阴道病的标准,常规诊断法(即湿涂片法)灵敏度为56%(95%可信区间为32%～78%),特异性为96%(95%可信区间为90%～100%),阳性预测值为83%,阴性预测值为85%。结论在无症状妊娠期患者中,可用革兰染色法对细菌性阴道病进行可靠诊断。
Objective To compare wet smear and Gram stain diagnoses of bacterial vaginosis among asymptomatic pregnant women.Methods Between September 1,2006 and January 31,2008,asymptomatic women who initiated prenatal care in our obstetric clinics were invited to participate.Clinical diagnosis that required two of three positive criteria for bacterial vaginosis（vaginal pH,whiff test,and clue cells on wet smear）was compared with Gram stain diagnosis（Bacterial vaginosis score 7-10 by Nugent criteria）.Results Population characterstics included an average matemal age of（27.3±6.6）years,26 nulliparas.The mean gestational age at entry was（15.6±7.6）weeks.Twenty-seven percent（18/67）of the study population was diagnosed with bacterial vaginosis by definitive Gram stain.Using Gram stain diagnosis of bacterial vaginosis as the standard,clinical diagnosis had sensitivity of 56%（95% confidence interval[CI]32%,78%）,aspecificity of 96%（95% contidence interval[CI]90%,100%）,a positive predictive value of 83%,and a negative predictive value of 85%.Conclusion In asymptomatic pregnant women,bacterial vaginosis can be diagnosed reliably by Gram stain.
出处
《国际检验医学杂志》
CAS
2010年第6期566-567,共2页
International Journal of Laboratory Medicine
关键词
阴道病
细菌性
妊娠
诊断
对比研究
vaginosis,bacterial
pregnancy
diagnosis
comparative study
