摘要
目的研究64层螺旋CT动态增强扫描结直肠癌肠外浸润的判别函数，以期提高结直肠癌肠外浸润诊断的准确性和特异性。方法回顾性分析2007年6月至2008年12月49例结直肠癌患者的49个肿块，术前行64层螺旋CT动态增强扫描。每个肿块取1～2个层面，共96个层面。根据病理结果将96个层面分为肠外浸润组和非肠外浸润组，将2组动态增强后各时间点（10、15、20、25、30、35、40、45、50、55、60、65、70、75s）肿块CT值与肿块处肠外5mm范围内组织的CT值的差值进行判别分析，求出结直肠癌肠外浸润的判别函数。将CT形态学判别肠外浸润的结果和求出的判别函数判别的结果与病理结果进行对照。应用方差分析比较2组各时间点CT值差值的差异性。结果肠外浸润组CT值差值范围为（43．6±27．8）-（52．3±30．8）HU，非肠外浸润组CT值差值范围为（100．4±20．3）～（116．2±21．4）HU。其中肠外浸润组20S和40s时的CT值差值分别为（43．6±27．8）和（50．9±27．8）HU；非肠外浸润组20s和40s时的CT值差值分别为（102．0±16．9）和（116．2±21．4）HU。2组各时间点CT值差值的差异有统计学意义（F=6．278，P〈0．01）。经判别分析，得到判别函数（D）=-3．450＋0．023X1＋0．017X2—0．001X12-0．001X；＋0．002X1×X2，其中X1表示20SCT值差值，X2表示40sCT值差值。根据结直肠癌cT形态学表现正确判断69个层面，误判27个层面，其中20个层面非肠外浸润误判为肠外浸润，诊断肠外浸润的敏感性为82．5％，特异性为64．3％，准确性为71．9％。应用判别函数正确判断85个层面，误判11个层面，其中5个层面非肠外浸润误判为肠外浸润，诊断肠外浸润的敏感性为85．0％，特异性为91．1％，准确性为88．5％。结论结直肠癌肠外浸润64层螺旋CT动态增强的判别函数可以提高肠外浸润诊断的准确性和特异性。
Objective To evaluate the efficacy of discriminant function analysis for pericolic infiltration in colorectal cancer on enhanced 64-slice spiral CT and to improve the diagnostic accuracy and specificity of pericolic infiltration. Methods Dynamic enhanced 64-slice spiral CT was performed in 49 colorectal cancer patients （49 masses in total） before surgery. One or two slices were selected for each mass, with a total of 96 shces. The 96 slices were classified into two groups （pericolic infiltration or non- pericolie infiltration group） according to pathological data. Discriminant analysis was performed on the CT values between the mass and the corresponding pcricolic tissue 5 mm from the mass at different time points as follows： 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, and 75 s. The discriminant function was calculated, and the pericolic infiltration determined by discriminant function and CT morphology were compared with the pathological results. The CT values in pericolic and non-pericolic infiltration groups at different enhancement time points were assessed using analysis of variance. Results The mean CT values ranged from （43.6±27.8） HU to （52. 3 ±30. 8） HU in the pericolic infiltration group, and ranged from （ 100. 4 ±20. 3 ） HU to （ 116. 2 ± 21.4 ） HU in the non-peficolic infiltration group. At 20 s and 40 s, the mean CT values were （ 43.6± 27. 8 ） HU and （ 50. 9 ± 27.8 ） HU in the pericolic infiltration group, （ 102. 0 ±16. 9） HU and （ 116. 2 ± 21.4 ） HU in the non- pericolic infiltration group, respectively. The mean CT value in the pericolic infiltration group was significantly lower than that in the non-pericolic infiltration group at all contrast enhancement time points （ F = 6. 278, P 〈 0. 01 ）. A discriminant function was obtained as follows： D = - 3.450 ＋ 0. 023X1 ＋ 0. 017X2 - 0. 001X1^2 - 0. 001X2^2 ＋ 0. 002X1 × X2. Based on the CT morphology of colorectal cancer, 69 slices were identified correctly and 27 slices were falsely interpreted, the sensitivity, specificity and accuracy for pericolic infiltration determination were 82. 5%, 64. 3% and 71.9%, respectively. Based on discriminant function, 85 slices were identified correctly and 11 slices were falsely interpreted, the sensitivity, specificity and accuracy were 85. 0%, 91.1% and 88. 5%, respectively. Conclusion The discriminant function with dynamic enhanced 64-slice spiral CT can improve the diagnostic accuracy and specificity of pericolic infiltration in colorectal cancer patients.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2010年第7期716-720,共5页
Chinese Journal of Radiology
基金
广东省科技计划基金资助项目（2007B031516007）
关键词
结直肠肿瘤
体层摄影术
X线计算机
判别分析
Colorectal neoplasms
Tomography, X-ray computed
Discriminant analysis
