摘要
目的:探讨针刺复合麻醉对体外循环心脏手术围手术期患者免疫功能的影响。方法:选择择期行体外循环房间隔缺损、室间隔缺损修补术、二尖瓣膜置换术及肺动脉瓣膜狭窄切开术的患者30例随机分为A、B两组,每组15例。A组采用全麻加电针内关、列缺、云门,B组单纯全麻,对围术期前后肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)、白介素-10(IL-10)的数据进行比较。结果:两组患者体外循环(CPB)后2h、CPB后24h血清中促炎性因子TNF-α均较术前上调表达,抗炎性因子IL-2、IL-10表达下调;两组间的炎性因子变化比较,在CPB后2h、CPB后24h这2个时间点,A组的促炎性因子的表达上调幅度较B组相对较小,而抗炎性因子的表达下调幅度亦相对较小,组间差异有统计学意义(均P<0.05)。结论:在控制麻醉深度相同的条件下,针药复合麻醉相对于单纯全麻,在围手术期能部分改善围术期免疫抑制。
Objective To explore the effect of acupuncture-drup compound anesthesia on immune function in patients with extracorporeal circulation undergoing cardiac surgery. Methods Thirty cases undergoing cardiac surgery which included atrial septal defect neoplasty, ventricular septal defect neoplasty, mitral valve replacement and pulmonary valve coarctotomy were randomly divided into group A and group B, 15 cases in each group. Group A was given general anesthesia plus acupuncture at Neiguan （PC 6）, Lieque （LU 7） and Yunmen （LU 2）, and group B was given simple general anesthesia. Tumor necrosis factor-alpha （TNF-a）, interleukin-2 （IL-2） and interleukin-10 （IL-10） levels before and after surgery were compared. Results The level of TNF-a was increased and the levels of IL-2 and IL-10 in the serum were decreased in both groups after extracorporeal circulation for 2 h and 24 h, and the ranges of all changes were more less in group A （all P〈0.05）. Conclusion Compared with simple general anesthesia, acupuncture-drug compound anesthesia can improve immune suppression partially in the perioperative periods under the same conditions of controlling anesthesia degree.
出处
《中国针灸》
CAS
CSCD
北大核心
2010年第7期585-588,共4页
Chinese Acupuncture & Moxibustion
基金
国家重点基础研究发展计划(973)资助项目:2007CB512504
