摘要
目的研究１５～６８岁中国人血清瘦素（ｌｅｐｔｉｎ）水平与体脂、年龄、性别及睾酮的关系。方法用放射免疫分析法测定７７例正常非肥胖和２８例超重或肥胖个体〔体重指数（ＢＭＩ）≥２５〕的血清瘦素水平。结果中国人正常非肥胖者平均瘦素浓度男性为（２．１５±１．４６）μｇ／Ｌ，女性为（７．８６±３．６０）μｇ／Ｌ；超重或肥胖者平均瘦素浓度男性为（４．８７±３．４７）μｇ／Ｌ，女性为（１６．５９±６．９２）μｇ／Ｌ，女性均较男性高约２～３倍。血清瘦素水平与ＢＭＩ显著相关（男子ｒ＝０．６９，Ｐ＜０．００１；女子ｒ＝０．６３，Ｐ＜０．００１），但２５％的肥胖个体仍存在有瘦素的相对性缺乏。结论血清瘦素水平与ＢＭＩ显著相关提示多数肥胖个体存在瘦素抵抗，部分瘦素相对性缺乏的肥胖者将有可能成为瘦素治疗的对象。
Objective To investigate the relationship between serum leptin concentration and body fat, gender, age and testosterone in Chinese. Methods The serum leptin concentrations were measured in 77 lean and 28 overweight or obese body mass index (BMI)≥25 subjects by RIA. Results The serum leptin concentrations in lean Chinese were (2.15±1.46)μg/L in male and (7.86±3.60)μg/L in female, while in overweight or obese ones they were (4.87±3.47)μg/L in male and (16.59±6.92)μg/L in female, which were 2～3 times higher in women than in men. In both men and women, in spite of a relative deficiency of leptin in 25% of obese persons, fastleptinlevelsweresignificantlycorrelatedwith BMI (r=0.69, P<0.001 in male and r=0.63, P<0.001 in female). Conclusion Serum leptin concentrations are correlated with BMI, suggesting that most obese persons are resistant to leptin. Those who are relatively deficient of leptin may become the good candidates for leptin treatment in the future.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1999年第1期15-18,共4页
Chinese Journal of Endocrinology and Metabolism
基金
美国RockefelLer Foundation资助
上海第二医科大学自然科学基金
关键词
瘦素
肥胖症
体重指数
Leptin Obesity Body mass index
