摘要
目的:探讨急性脑梗死(ACI)早期血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)的变化及其意义。方法:用酶联免疫吸附法,测定30例健康对照者和35例急性脑梗死(ACI)患者发病6 h内的血清TNF-α和IL-6水平,并对患者进行神经功能缺损评分(NDS),用spearman等级相关方法检验相关性。结果:ACI患者血清TNF-α和IL-6均明显高于健康对照组,两者与发病6 h内的NDS及其进展均呈显著正相关(前者rs分别为0.89和0.93,后者为0.90和0.91,P均(0.001),进展型脑梗死组(PCI)早期血清TNF-α和IL-6明显高于稳定性脑梗死组(SCI),分别为(49.56±12.12)ng/Lvs(24.30±7.40)ng/L和(39.76±7.88)ng/Lvs(20.78±6.28)ng/L,P均(0.01。结论:ACI患者早期血清TNF-α和IL-6明显升高,并与病情密切相关,PCI组早期血清TNF-α和IL-6明显高于SCI患者,TNF-α和IL-6对PCI风险评估有一定预测价值。
Objective： To investigate the change of early serum TNF-α and IL-6 levels in acute cerebral infarction and its significances.Methods： Serum TNF-α and IL-6 levels in 30 health subjects and 35 patients with acute cerebral infarction（ACI） within 6 hours of onset were measured by enzyme linked immunosorbent assay（ELISA）;neurological deficits scores（NDS） in all cases were determined,and Spearman test was used for correlation.Results： The serum levels of TNF-α and IL-6 in ACI group were markedly higher than those in health subjects and there was a positive correlation of TNF-α and IL-6 levels with 6 h NDS（rs=0.89 and 0.93,P0.001） and with NDS progression（rs =0.90 and 0.91,P﹤0.001）.Early serum TNF-α and IL-6 levels in progressive cerebral infarction（PCI） group were evidently higher than those in stable cerebral infarction（SCI） [（49.56±12.12）pg/L vs（24.30±7.4）ng/L and（39.76±7.88）ng/L vs（20.78±6.28）ng/L,respectively,P0.01）].Conclusion： The early serum levels of TNF-α and IL-6 in ACI markedly increase and are closely correlated with disease severity;which may be of value in PCI risk evaluation.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2010年第4期415-418,共4页
Journal of Zhejiang University(Medical Sciences)
基金
苍南县科技局社会科技发展项目(2007S18)
关键词
脑梗死
急性病
肿瘤坏死因子α
白细胞介素类
酶联免疫吸附测定
白介素6
进展性脑梗死
价值
Brain infarction
Acute disease
Tumor necrosis factor-alpha
Interleukins
Enzyme-linked immunosorbent assay
Inferleukin-6
Progressive cerebral infarction
Value
