摘要
间充质干细胞(mesenchymal stem cells,MSC)能抑制T细胞的增殖,对不同的T细胞亚群表现出不同的免疫调节效应,其机制主要包括细胞-细胞接触和MSC分泌的细胞因子介导。令人鼓舞的是,最近有研究表明MSC影响T细胞对病原体的反应并不明显,但能显著抑制T细胞对同种异体抗原的反应。此外,MSC能调节B细胞的增殖、存活、抗体分泌和分化,能抑制DC的生成、增殖、抗原呈递和迁移能力,调节DC的分化、成熟,能调节NK细胞(自然杀伤细胞)增殖、细胞毒和分泌细胞因子的功能。本文就MSC对各种免疫细胞(T淋巴细胞、B淋巴细胞、NK细胞和DC细胞)的调节作用的研究进展进行了总结。
Mesenchymal stem cells （MSCs） can inhibit T cell proliferation, the effects of MSCs on various T cell subsets have showed different immune regulatory reactions, and their mechanisms mainly include cell-cell contact and mediation by cytokines secreted from MSCs. Encouragingly, recent studies have showed that the effects of MSCs on T- cell response to pathogens is not significant, but can obviously suppress T cell response to allogeneic antigens. In addition, MSCs can regulate the proliferation, survival, antibody secretion and differentiation of B cells, inhibit the production, proliferation, migration and antigen-presentation of DCs, and modulate the differentiation and maturation of DCs, and regulate the proliferation, cell toxicity and cytokine secretion of NK cells. In this review, the research advances on immunomodulatory effects of MSCs on various immune ceUs including T-lymphocytes, B-lymphocytes, NK cells and DCs are summarized with emphasis on the immunoregulatory effects of MSCs on T-lymphocytes.
出处
《中国实验血液学杂志》
CAS
CSCD
2010年第4期1079-1083,共5页
Journal of Experimental Hematology
基金
福建省科自然科学基金资助
编号2007J0084
关键词
间充质干细胞
免疫细胞
免疫调节
mesenchymal stern cells
immune cells
immunoregulation
