摘要
目的比较喹硫平及喹硫平合并碳酸锂治疗双相Ι型障碍躁狂发作的疗效和安全性。方法将符合美国精神疾病诊断与统计手册第4版(DSM-)双相Ι型障碍躁狂发作诊断标准的患者64例,随机分为喹硫平组和喹硫平合并碳酸锂组,疗程4周,以杨氏躁狂量表(YMRS)、临床大体印象量表(CGI)和副反应量表(TESS)评定疗效及不良反应。结果在治疗的第4周末,喹硫平组痊愈率83.9%,有效率93.5%,喹硫平合并碳酸锂组痊愈率83.3%,有效率93.3%。两组痊愈率、有效率比较均无显著性差异;YMRS量表评分,治疗后均较治疗前有显著性下降(P<0.05),并随着治疗时间的延续均呈持续性下降。治疗第1、2、3、4周末YMRS量表评分两组组间比较均无显著性差异(P>0.05)。在不良反应方面,单药治疗组明显少于联合治疗组,差异有统计学意义(χ2=5.391,P<0.05)。在喹硫平的用药剂量上,联合治疗组明显少于单药治疗组,差异有统计学意义(P<0.05)。结论喹硫平及喹硫平合并碳酸锂治疗双相Ι型障碍躁狂发作疗效相当,均有良好疗效但喹硫平单药治疗不良反应小,安全性高。
Objective To observe and compare the efficacy and safety of the treatment in miplor I type manic disorder between quetiapine and quetiapine combinated lithium carbonate.Methods A total of 64 patients fit for the Diagnostic and Statistical Manual fourth edition （DSM-Ⅳ） diagnostic criteria for panic disorder were randomly divided into two groups treated respectively by quetiapine and quetiapine combinated lithium carbonate,with 4-week course of treatment respectively by A Rating Scale for Mania（YMRS）、Climical Global Imperessioms（CGI） and Emergent Symptom Scale （TESS） to assess the efficacy and adverse reactions.Results At the end of the fourth week in duration,the cure rate and efficient rate of the qutimate group were respectively 83.9% and 93.5%,the cure rate and efficient rate of the other group were respectively 83.3% and 93.3%.There were no significant differences between two groups with cure rate and efficient rate.The score of YMRS was significantly lower than before and continuously dropped with the time go on （P0.05）.There were no significant difference between two groups at end of the first,second,third,fourth week after treatment（P0.05）. The quetiapine group was obviously less than the combination group in reverse reaction （χ2=5.391,P0.05）. The combination group was obviously lower dosage than the quetiapine group （P0.05）.Conclusion Quetiapine has the same good efficacy in treatment of miplar I tye manic disorder as quetiapine cimbinated lithium carbonate. But quetiapine is more safe and less reverse reaction than quetiapine combinated lithium carbonate.
出处
《中国健康心理学杂志》
2010年第8期902-904,共3页
China Journal of Health Psychology
关键词
躁狂发作
喹硫平
喹硫平合并碳酸锂
对照研究
Manic disorder
Quetiapine
Quetiapine combinated lithium
Control study
