老年ACS患者sFas、MMP-2水平与易损斑块相关性研究被引量：1

Study on the Correlation Between the Levels of sFas or MMP-2 and Vulnerable Plaque in Aged Patients with ACS

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摘要【目的】检测老年急性冠脉综合征（ACS）患者外周血中可溶性凋亡相关因子（sFas）和基质金属蛋白酶2（MMP-2）水平，评价动脉粥样硬化斑块的易损性，并从血清学角度评价细胞凋亡和易损斑块之间的相关性。【方法】应用酶联免疫吸附法（ELISA）法测定218例患者外周血血清sFas、MMP-2水平，入选病例分为老年组139例和成年组79例，各分为ACS[包括不稳定心绞痛（UAP）（老年组31例，成年组11例），急性非ST段抬高心肌梗死（NSTEMI）（老年组19例，成年组9例），急性ST段抬高心肌梗死（STEMI）（老年组66例，成年组26例）]组；稳定性心绞痛（SAP）组（老年组9例，成年组13例）和对照组（老年组14例，成年组20例）。【结果】①老年ACS组sFas、MMP-2水平（分别为727．38±193．65pg／mL和57．59±20．52ng／mL），显著高于成年ACS组（分别为598．01±147．18pg／mL和50．65±18．82ng／mL），P〈0．05。②sFas和MMP-2水平有显著的正相关性，Pearson检验相关系数为r=0．306，P〈0．01。【结论】①细胞凋亡与易损斑块形成相关。②老年ACS患者动脉粥样硬化斑块处细胞凋亡程度更高，斑块稳定性更差。 [Objective] To detect the peripheral blood levels of soluble factor associated suicide（sFas） and matrix metalloproteinase-2（MMP-2） in aged patients with acute coronary syndrome（ACS）, and evaluate the stability of coronary plaque, and estimate the correlation between cell apoptosis and vulnerable plaque. [Methods] Enzyme-linked immunosorbent assay（ELISA） was used to detect serum sFas and MMP2 levels in 218 patients. These patients were divided into aged group （ n = 139） and adult group（ n = 79）, and each group was divided into ACS group involving unstable angina pectoris （UAP）（31 patients in aged group and 11 patients in adult group）, acute myocardial infarction without ST segment＇s elevation （NSTAMI） group（19 patients in aged group and 9 patients in adult group）, AMI with ST segment＇s elevation（STEMI） group（66 patients in aged group and 26 patients in adult group）, stable angina pectoris（SAP） group（9 patients in aged group and 13 patients in adult group） and control group（14 patients in aged group and 20 patients in adult group）. [Results] The levels of sFas and MMP-2 in aged ACS group were 727.38± 193.65pg/mL and 57.59±20.52ng/mL which were higher than those in adult ACS group（598.01±147. 18pg/mL and 50. 65±18. 82ng/mL）（ P 〈0.05）. There was significantly positive correlation between sFas and MMP-2. The Pearson coefficient correlation（r） was 0. 306（ P 〈0.01）. [Conclusion] Celt apoptosis is correlated with the formation of vulnerable plaque. In the aged ACS group, the apoptosis degree of the atherosclerosis plaque is significantly higher, and the atherosclerosis plaque is more unstable.

作者宿慧张健

机构地区北京世纪坛医院首都医科大学附属北京友谊医院

出处《医学临床研究》 CAS 2010年第8期1413-1415,共3页 Journal of Clinical Research

关键词冠状动脉疾病/病理学抗原 CD95/分析金属蛋白酶类/分析 coronary disease/PA antigens,CD95/AN metalloproteinases/AN

分类号 R543.3 [医药卫生—心血管疾病]

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