摘要
骨肉瘤是实体性的肿瘤且血运丰富,其生长和转移都有依赖于肿瘤中血管的生成。已发现多种骨肉瘤血管生成相关的因子,其中一些血管生成因子和患者的预后及病程转归密切相关。文中就近年发现和骨肉瘤预后相关的血管生成因子:血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶(matrix metalloproteinase,MMP)、血小板衍生生长因子(platelet-derived growth factor,PDGF)、表皮生长因子受体(epidermal growth factor receptor,EGFR)、色素上皮衍生因子(pigment epithelium-derived factor,PEDF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)做一综述。
The growth and metastasis of osteosarcoma depend on angiogenesis in the tumor.A number of measurable markers related to tumor angiogenesis have been studied in patients with osteosarcoma,and some of them are closely associated with the important clinical features of the disease,serving to predict its clinical course in a particular patient and identify the patient for possible antiangiogenic therapy.This article presents an overview of the main angiogenesis factors related to the prognosis of osteosarcoma,including the vascular endothelial growth factor（VEGF）,matrix metalloproteinase（MMP）,platelet-derived growth factor（PDGF）,epidermal growth factor receptor（EGFR）,pigment epithelium-derived factor（PEDF）,and basic fibroblast growth factor（bFGF）.
出处
《医学研究生学报》
CAS
2010年第8期884-888,共5页
Journal of Medical Postgraduates
基金
全军医学科研"十五"计划杰出人才基金(04J005)
关键词
骨肉瘤
血管生成因子
预后
Osteosarcoma
Angiogenesis factors
Prognosis
