摘要
目的:观察"截断逆挽法"治疗慢性乙型重型肝炎方案的有效性。方法:前瞻性随机将慢性乙型重型肝炎患者分为治疗组55例,对照组56例,分别给予中西医结合治疗和单纯西药治疗4周,随访8周,观察有效率、症状及主要化验指标的改善情况。结果:证候积分疗效:治疗组总有效率(40例,72.73%)高于对照组(30例,53.57%),两组比较差异有显著性意义(P<0.05)。肝功能:①胆红素:两组患者治疗两周后TBil明显下降,其中治疗组两周后与治疗前比较,差异有显著性意义(P<0.05);治疗组4周后与治疗前比较,差异有非常显著性意义(P<0.01);对照组8周后与治疗前比较,差异有显著性意义(P<0.05)。②凝血功能:治疗组患者凝血酶原活动度(PTA)明显升高,治疗1周后PTA(43.6%)与治疗前(35.0%)比较,差异有非常显著性意义(P<0.01);对照组患者PTA治疗前后无明显变化。综合疗效:治疗组有效率(37例,67.27%)高于对照组(30例,53.57%),两组比较差异无显著性意义(P>0.05);治疗组病死率(5例,9.09%)低于对照组(13例,23.21%),两组比较差异有显著性意义(P<0.05)。结论:中西医结合疗法在降低病死率,改善症状、改善肝功能(退黄、提高凝血酶原活动度)等方面均优于单纯西药对照组,验证了"截断逆挽法"治疗慢性乙型重型肝炎方案的有效性。
Objective：To evaluate initially therapeutic effect of the Jieduan Niwan method on chronic severe hepatitis B.Methods：About 110 patients were selected and received the treatment of TCM and western medicine or the treatment of only western medicine,to evaluate initially the effect by the comparison of effective rate,frequency of complication,case fatality rate and the main laboratory indexes.Results：First The effect on syndrome：After eight weeks＇treatment,the effective rate （40cases,72.73%） in the treatment group was higher than in the control group （30 cases,53.57%）,and the difference between them was significant （P〈0.05）.Second The effect on liver function：①Total bilirubin （TBil）：After two weeks＇ treatment TBil of the two groups decreased remarkably.And the difference in the treatment group was all significant compared TBil before treatment with after two weeks＇treatment （P〈0.05）,four week＇s treatment （P〈0.01） and eight weeks＇treatment （P 0.05）.②Blood cloting function：in the treatment group PTA was significant increased after treatment.And the difference between on week＇s therapy （43.6%） and pretherapy （35.0%） was significant （P〈0.01）.But there was no significant difference in the control group.After one week＇s treatment PTA in the treatment group （43.6%） was higher remarkably than in the control group （33.4%）,and the difference was remarkably significant （P〈0.01）.Third The compositive effect：The effective rate （37 cases,67.27%） in the treatment group was higher than in the control group （30 cases,53.57%）,and the difference between them was not significant （P〈0.05）.The case fatality rate （5 cases,9.09%） in the treatment group was lower than in the control group （13 cases,23.21%）,and the difference between them was significant （P〈0.05）.Conclusion：The effect in the treatment group was better than in the control group,especially in recoverying syndrome,liver function （such as TBil,blood cloting function） etc.Which proved the rationality of the principle.
出处
《中西医结合肝病杂志》
CAS
2010年第4期200-203,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
北京市中医发展基金(No.JJ2005-21)
北京市科委国家传染病专项对接基金(No.D08050700630802)
首都医学发展科研基金(No.SF-2007-Ⅲ-24)
关键词
截断逆挽法
重型肝炎
乙型
慢性
辨证论治
疗效评价
Jieduan Niwan method
chronic severe hepatitis B
diagnosis and treatment based on differentiation of symptoms and signs
therapeutic effect evaluation
