摘要
目的:探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者血清真胰岛素(TI)、胰岛素原(PI)与体脂分布的相关性。方法:根据呼吸暂停低通气指数(AHI)将72例确诊的OSAHS患者分为轻度组、中度组及重度组3组,同时选择15例健康正常人作为对照组,采用高度特异性的酶联免疫吸附试验(ELISA)法分别检测空腹血清TI、PI水平,同时测定体质量指数(BMI)、腰围(WC)、颈围(NC)。结果:OSAHS患者血清TI、PI的水平均高于对照组(P<0.05)。OSAHS中、重度组的TI、PI水平明显高于轻度组(P<0.05)。OSAHS患者血清TI、PI与BMI、WC、NC呈正相关。结论:OSAHS患者血清TI、PI的水平与体脂分布存在相关性。
Objective： To study the relationship between serum true insulin （TI）, proinsulin（PI） and the body fat distribution in patients with obstructive sleep apnea- hypopnea syndrome （OSAHS）. Methods： Seventy-two OSAHS patients were divided into three groups, mild group, moderate group and severe group according to apnea hypopnea index （AHI）, meanwhile 15 healthy people were selected as control group. The serum levels of TI, PI and body mass index（BMI）, waist circumference （WC）, neck circumference（NC） were detected in four groups. Results： The levels of PI and TI were higher in OSAHS group than those of control group, and there were significant differences between four groups（P 0.05）. The results of Pearson analysis indicat- ed that the levels of TI and PI were positively correlated with BMI, WC and NC in OSAHS patients. Conclusion： Both serum levels of TI and PI were correlated to body fat distribution in OSAHS patients.
出处
《天津医药》
CAS
北大核心
2010年第8期648-650,共3页
Tianjin Medical Journal
基金
贵阳市科技基金资助项目[项目编号:(2007)筑科农字第22号]
