摘要
目的 观察不同年龄重度烧伤患者应用外源性生长激素的血糖变化.方法 将140例既往无糖尿病史的不同年龄段重度烧伤患者根据世界卫生组织对年龄段的划分标准,分为A组（18～44岁,即青年组）和B组（≥45岁,即中、老年组）,各70例.再采用表格随机法将A、B两组分成使用0.2 IU·kg^-1·d^-1生长激素的A1组、B1组和使用安慰剂（等渗盐水）的A0组、B0组,每组均35例.观察受试者血糖水平变化及胰岛素控制的用量,并进行分析探讨.结果 140例入组的患者共128例完成实验,各组之间一般情况差异无统计学意义（P＞0.05）,在入院4周内完成试验,A1、A0两组胰岛素用量分别为（2 908.0±153.5）IU和（724.1±31.1）IU,B1、B0两组胰岛素用量分别为（3 725.9±88.4）IU和（801.8±22.2）IU.结果 显示,中、老年组比青年组、使用生长激素组比不使用生长激素组需要胰岛素控制的例数多、用量大,差异均有统计学意义（P＜0.01）.A1、B1组出现高血糖的患者停用生长激素后血糖恢复正常（不需要胰岛素控制）的时间分别为（5.21±0.64）d、（5.03±1.01）d（P＞0.05）.结论 重度烧伤患者应用生长激素后血糖水平升高,年龄与血糖变化呈正相关,规范应用生长激素治疗不会导致糖尿病.
Objective To observe the changes of blood sugar following use of recombinant human growth hormone （rhGH） in patients with severe burn. Methods A total of 140 patients with severe burn but with no history of diabetes were randomly and equally divided into Group A （ 18-44 years old） and Group B （ ≥45 years old） according to WHO criteria. Then, two groups were randomly divided into Group A1 and Group B1 （treated with 0.2 IU/kg · d growth hormone） as well as Group A0 and Group B0 （treated with normal saline） , 35 patients per group. Change of blood sugar and amount of insuline for control of blood sugar were observed and analyzed. Results Of 140 patients in four groups, 128 patients accomplished the test, with no statistical difference upon general conditions between groups （ P 〉 0.05 ）. Within four weeks after test, the amount of insuline used for control of blood sugar was （2908.0 ±153.5 ） IU and （724.1 ±31.1 ） IU respectively in Groups A1 and A0, （3725.9 ±88.4） IU and （801.8 ±22.2） IU respectively in Groups B1 and B0. The resuhs showed that the patients needing insulin to control blood sugar in Group B were more than that in Group A （P 〈0.01 ）. The time for blood sugar recovering to normal range in patients with high blood sugar with no use of rhGH in Group A1 and Group B1 was （5.21 ±0.64） d and （5.03 ±1.01） d respectively （P〉0.05）. Conclusions The blood sugar of patients with severe burn will rise after use of rhGH. The age of the patients is positively correlated with changes of blood sugar. Standard use of rhGH does not induce diabetes.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2010年第8期749-751,共3页
Chinese Journal of Trauma
基金
浙江省医药卫生科技成果重点推广计划资助项目（2006TG026）
关键词
重组人生长激素
血糖
烧伤
Recombinant human growth hormone
Blood sugar
Burn
