摘要
目的了解2007-2009年新生儿病房医院感染的病原菌分布特点及其耐药性变化,为临床合理使用抗菌药物提供依据。方法对新生儿病房2007年6月-2009年7月所分离出的病原菌菌株及其耐药性进行回顾性调查分析。结果所有送检标本共检出病原菌124株,其中革兰阴性菌110株,占88.7%,革兰阳性菌12株,占9.7%,真菌2株,占1.6%,前4位病原菌依次为肺炎克雷伯菌、大肠埃希菌、凝固酶阴性葡萄球菌和铜绿假单胞菌;肺炎克雷伯菌和大肠埃希菌对常用抗菌药物耐药严重,且呈多药耐药,肺炎克雷伯菌ESBLs的检出率为94.1%,大肠埃希菌ESBLs的检出率为36.4%。结论进行病原学监测,了解病原菌株分布及其耐药趋势,对合理选择抗菌药物、降低新生儿感染发生率和死亡率以及减少耐药菌株产生均有重要价值。
OBJECTIVE To investigate the clinical distribution characteristics and drug resistances of pathogens in neonatal ward from 2007 to 2009,and instruct clinical application of antibiotics reasonably.METHODS A retrospective investigation analysis was made for all the isolated pathogens as well as their drug resistances in neonatal ward from Jun 2007 to Jul 2009.RESULTS The results showed that 124 strains of pathogens were isolated from all detected samples,which included 110 strains of G-bacteria（88.7%）,12 strains of G＋ bacteria（9.7%） and 2 strains of fungi（1.6 %）.Klebsiella pneumoniae,Escherichia coli,Coagulase negative Staphylococcus and Pseudomonas aeruginosa were the most frequently isolated pathogens.The pathogens were highly resistant to commonly used antimicrobials and demonstrated multi-drug resistance.The ESBLs producing strains in K.pneumoniae and E.coli were 94.1 % and 36.4%,respectively.CONCLUSION Inspecting pathogens and studying the trend of their drug resistance are important for rationally select antibiotics,reducing infection incidence and mortality rate,and decreaseing the occurrence of drug resistant strains in neonates.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第17期2696-2698,共3页
Chinese Journal of Nosocomiology
关键词
新生儿病房
病原菌
耐药性
Neonatal ward
Pathogen
Drug resistance
