摘要
目的比较胰岛素及胰岛素联合吡格列酮治疗口服降糖药失败的2型糖尿病患者的疗效。方法将58例磺脲类降糖药治疗失败的2型糖尿病患者随机均分为两组,对照组29例给予胰岛素治疗,治疗组29例给予胰岛素联合吡格列酮治疗,疗程均为12周。分别观察两组患者空腹血糖、糖化血红蛋白(HbA1C)、胰岛素用量以及血脂变化情况。结果两组患者治疗后血糖和HbA1C均控制良好,其中治疗组胰岛素日需求量明显低于对照组(P<0.05),血脂较对照组明显改善,甘油三酯较对照组下降,高密度脂蛋白胆固醇较对照组升高(P<0.05)。结论胰岛素联合吡格列酮治疗口服降糖药失败的2型糖尿病患者,血糖和HbA1C均控制良好,同时可减少胰岛素用量,改善脂质代谢。
Objective To observe the effects of insulin combined with pioglitazone on type 2 diabetes mellitus failed to oral hypoglycemic drugs.Methods 58 patients with type 2 diabetes mellitus failed to sulforylureas were randomly divided into the control group and treatment group.29 patients in the control group were treated by insulin and the other 29 patients in the treatment group were treated by insulin combined with pioglitazone for 12 weeks.The fasting blood glucose （FBG）,hemoglobin A1C （HbA1C）,blood lipid （TC,TG,LDL-C and HDL-C） and insulin dosage were detected before and after treatment for evaluating the clinical curative effect.Results In all cases,the level of FBG,2 h PBG,HbA1C were decreased after treatment.The insulin daily dosage in the treatment group was obviously lower than that in the control group.Moreover,in the treatment group the level of HDL-C was increased and the level of TC,TG,and LDL-C was decreased significantly compared with the control group.Conclusion Insulin combined with pioglitazone has more prominently curative effect on type 2 diabetes mellitus failed to sulfonylureas,at the same time,which can reduce the insulin dosage and improve lipid metabolism.
出处
《中国药业》
CAS
2010年第17期60-61,共2页
China Pharmaceuticals
关键词
胰岛素
吡格列酮
糖尿病
insulin
pioglitazone
diabetes mellitus
