摘要
近年来,深部真菌感染的发生率和死亡率不断升高,研发全新结构类型和全新作用机制的抗真菌药物具有重要意义。本文综述了2007年至2009年新报道的抗真菌先导化合物,并对其化学结构、抗真菌活性和构效关系进行总结,为未来抗真菌新药研究提供指导信息。
In recent years,the incidence and mortality rate of invasive fungal infection have increased dramatically,and it is of great significance to develop novel antifungal agents with new chemical structure and new mode of action. In this review,novel antifungal lead compounds reported from 2007 to 2009 are reviewed. Moreover,their chemical structures,antifungal activities and structure-activity relationships have been summarized,which can provide useful information for future study of antifungal agents.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第8期966-975,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(30930107)
关键词
抗真菌
先导化合物
构效关系
antifungal
lead compounds
structure-activity relationship
