摘要
目的探讨口服碘[131I]治疗功能自主性甲状腺腺瘤(AFTA)的临床疗效。方法回顾性分析14例AFTA患者,按照临床规范技术操作确诊后并经患者知情同意,给予碘[131I](投入剂量555~1110 MBq)口服治疗。在患者治疗前及治疗后3、6、12个月检测血清T3、T4、TSH、FT3、FT4;服药前后进行甲状腺显像,观察腺瘤在治疗前后的变化。结果应用131I治疗后1~2个月,瘤体明显缩小,治疗后3~6个月甲状腺显像"热结节"均消失,甲状腺正常组织显影;3个月后血清甲状腺激素水平明显下降;6个月后78.57%的患者甲状腺功能正常,甲状腺功能亢进症状基本消失;1年后甲状腺功能恢复正常者占92.86%。1例在治疗7个月后甲状腺功能减低,经口服优甲乐治疗后甲状腺功能恢复正常。结论口服碘[131I]治疗功能自主性甲状腺腺瘤是一种安全有效的方法。
Objective To explore the clinical effect of 131I radiotherapy in treatment of autonomously functioning thyroid adenoma（AFTA）.Methods Fourteen AFTA patients took 131I orally at the dose of 555-1110 MBq.The level of serum T3,T4,TSH,FT3 and FT4 were measured before and 3,6,and 12 months after treatment,respectively.Thyroid imaging with 99mTcO-4 or 99mTc-MIBI was conducted before and 3,6,and 12 months after treatment respectively,and the change of adenoma was observed.Results Thyroid imaging showed that the adenomas of all patients shrank significantly 1-2 months after 131I treatment,all the hot nodules disappeared,and normal thyroid tissues was shown in the imaging 3-6 months after treatment.Since 3 months after the treatment,the level of serum thyroid hormones began decrease obviously.Six months later,the thyroid functions became normal and the symptoms of hyperthyroidism disappeared in 78.57% of the patients,and 1 year later the thyroid functions resumed normal in 92.86% of the patients.One patient showed hypothyroidism 7 months after the treatment,whose thyroid functions returned to normal after orally taking Euthyrox.Conclusion Orally 131I treatment is a safe and effective method in treatment of AFTA.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第8期1546-1548,共3页
Chinese Journal of Medical Imaging Technology
基金
973项目(2006CB705705-1)
教育部985II期项目(985-2-056)
