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调强放疗保护N_0鼻咽癌患者颌下腺的研究 被引量：1

Sparing the submandibular glands by intensity modulated radiotherapy in the treatment of N_0 neck nasopharyngeal carcinoma
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摘要 目的:探讨调强放疗保护N0鼻咽癌患者颌下腺的可行性。方法:选择N0鼻咽癌患者10例,对每个病例分别制定保护颌下腺的调强放疗计划(计划A)和不保护颌下腺的调强放疗计划(计划B),比较两种计划的颌下腺、靶区和正常组织/危及器官的剂量分布、剂量体积直方图(DVH)等指标。结果:计划A和计划B相比,前者明显降低了颌下腺的照射剂量:左侧颌下腺D50分别为50.88Gy和30.96Gy,降低了19.92Gy(39.15%),D平均分别为50.27Gy和31.16Gy,降低了19.11Gy(38.01%);右侧颌下腺D50分别为50.71Gy和31.27Gy,降低了19.44Gy(38.34%),D平均分别为49.79Gy和31.73Gy,降低了18.06Gy(36.27%)。两种计划中靶区剂量无明显差别:GTV的D99分别为67.29Gy和67.62Gy,GTV的D95分别为69.59Gy和69.22Gy,GTV的D1分别为73.64Gy和73.64Gy,GTV的Daverage分别为71.21Gy和70.92Gy,GTV的Dmin分别为66.95Gy和66.79Gy;CTV1的D95分别为63.12Gy和63.32Gy,CTV1的Daverage分别为67.62Gy和67.29Gy,CTV1的Dmin分别为56.94Gy和56.45Gy;CTV2的D95分别为54.35Gy和54.65Gy,CTV2的Daverage分别为61.03Gy和60.83Gy,CTV2的Dmin分别为42.62Gy和42.72Gy。脑干的D1和D5、脊髓的D1、颞叶D5、颞颌关节的D50、腮腺的D50及D平均剂量两种计划比较差别不明显。结论:利用调强放疗可以安全有效地保护N0鼻咽癌患者的颌下腺,从而有可能进一步降低患者的口干症状。 Objective：To explore the feasibility of sparing the submandibular glands by intensity modulated radiotherapy in the treatment of N0 neck nasopharyngeal carcinoma.Methods：Ten patients with N0 neck nasopharyngeal carcinoma were selected.Two IMRT plans were designed for each patient.Plan A：sparing submandibular glands;Plan B：non-sparing submandibular glands.The dose distribution and dose volume histograph（DVH） of submandibular glands ,target and organs at risk（OAR） of two IMRT plans were compared.Results：The D50 to the left submandibular gland were 50.88Gy and 30.96Gy respectively in the plan A and plan B and to the right submandibular gland were 50.71Gy and 31.27Gy respectively.The arerage dose to the left submandibular gland were 50.27Gy and 31.16Gy respectively in the plan A and plan B and the right submandibular gland were 49.79Gy and 31.73Gy respectively.Plan A showed 39.15% and 38.34% decrease of D50 to the left and right submandibular gland and 38.01% and 36.27% decrease of arerage dose to the left and right submandibular gland.There were little difference in target＇s D99,D95,D1,Daverage and Dmin.Also there were little difference in the D1/D5/D50/Daverage of organs at risk（OAR）.Conclusion：Submandibular gland sparing with IMRT is safe and effective in the treatment of N0 neck nasopharyngeal carcinoma and decrease the degree of radiation-associated xerostomia.
作者 胡英 曾彪 吴湘玮 倪千禧 李中伟
机构地区 湖南省肿瘤医院放射治疗科
出处 《现代肿瘤医学》 CAS 2010年第9期1723-1726,共4页 Journal of Modern Oncology
关键词 鼻咽癌 调强放疗 颌下腺 nasopharyngeal carcinoma intensity modulated radiotherapy submandibular gland
分类号 R739.62 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Qiuwen Wu,Matthew Manning.The potential Ifor sparing of parotid ang sealation of biologically effective dose with intensity-modulated radiation treatment of head and neck cancers:a treatment design study[J].Int J Radiat Oncol Biol Phys,2000,46(1):195-205.
  • 2Eisbruch A,Rhodns N,Rosenthal D,et al.How should we measure and report radiotherapy-induced xerostomia[J] ? Semin Radiat Oncol,2003,3(13):226-234.
  • 3Jellema AP,Doornaert P,Slotman BJ,et al.Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy[J] ? Radiother Oncol,2005,77(2):164-171.
  • 4Jha N,Seikaly H,Harris J,et al.Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space[J].Radiother Oncol,2003,66 (3):283-289.
  • 5Pathak KA,Bhalavat RL,Mistry RC,et al.Upfront submandibular salivary gland transfer in pharyngeal cancers[J].Oral Oncol,2004,40(9):960 -963.
  • 6刘学奎,曾宗渊,洪明晃,崔念基,苏勇,麦海强,陈福进.颌下腺移位术预防鼻咽癌放疗后口干燥症的近期效果[J].癌症,2005,24(5):577-581. 被引量：17
  • 7Eisbruch A,Tan Haken RK,Kim HM,et al.Dose,volume and function relationships in paretid glands following conformal and intensity modulated irradiation of head and neck cancer[J].Int J Radiat Oncol Biol Phys,1999,45(3):577-587.
  • 8Eisbruch A,Kim HM,Terrell JE,et al.Xeroetemia and its predlctots following parctid-sparing irradiation of head and neck cancer[J].Int J Radiat Oncol Biol Phys,2001,50(3):695-704.
  • 9张春,潘建基,张瑜,柏朋刚,张秀春,王根桃.鼻咽癌适形调强放疗对腮腺功能影响的前瞻性研究[J].实用癌症杂志,2007,22(4):380-383. 被引量：8

二级参考文献23

  • 1潘建基,郑步宏,张瑜,陈传本,李金莲,张秀春.鼻咽癌适形放疗中摆位误差的测定[J].癌症,2006,25(1):115-118. 被引量：14
  • 2林端瑜,唐明灯,潘建基,张春,金星.核素显像法观察放射治疗对鼻咽癌患者腮腺功能的影响[J].福建医药杂志,2006,28(3):9-11. 被引量：3
  • 3Mossman K, Shatzman A, Chencharick J. Long-term effects of radiotherapy on taste and salivary function in man [J]. Int J Radiat Oncol Biol Phys, 1982,8 (6): 991-997.
  • 4Fox PC, van der Ven PF, Sonies BC, et al. Xerostomia:evaluation of a symptom with increasing significance [J]. J Am Dent Assoc, 1985,110(4) :519-525.
  • 5Jha N, Seikaly H, McGaw T, et al. Submandibular salivary gland transfer prevents radiation induced xerostomia [J]. Int J.Radiat Oncol Biol Phys, 2000,46( 1 ): 7-11.
  • 6Seikaly H, Jha N, McGaw T, et al. Submandibular gland transfer: a new method of preventing radiation-induced xerostomia [ J ]. Laryngoscope, 2001,111 (2): 347-352.
  • 7Wijers OB, Levendag PC, Braaksma MM, et al. Patients with head and neck cancer cured by radiation therapy: a survey of the dry mouth syndrome in long-term survivors [J]. Head Neck, 2002,24 (8): 737-747.
  • 8Sas R, Dawes C. The intraoral distribution of unstimulated and chewing-gum-stimulated parotid saliva [J]. Arch Oral Biol,1997,42(7) :469-474.
  • 9Kuten A, Ben-Aryeh H, Berdicevsky I, et al. Oral side effects of head and neck irradiation: correlation between clinical menisfestations and laboratory data [J]. Int J Radiat Oncol Biol Phys, 1986,12(3) :401-405.
  • 10Milne RW, Dawes C. The relative contributions of different salivary glands to the blood group activity of whole saliva in humans [J]. Vox Sang, 1973,25(4):298-307.

共引文献23

同被引文献9

  • 1Wei WI,Sham JS,2005.Nasopharyngeal carcinoma.Lancet..2005,365(9476),2041-2054.
  • 2Al-Sarraf M,Le Blanc M,Giri PG,et al,1998.Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer:phase III randomized Intergroup study 0099.J Clin Onco.998,16(4),1310-1317.
  • 3Young YH,Lu YC,2001.Mechanism of hearing loss in irradiated ears:a long-term longitudinal study.Ann Otol Rhinol Laryngo.2001,110(10),904-906.
  • 4Lawrence B.Marks,Ellen D.Yorke,Andrew Jackson,et al,2010.The Use of Normal Tissue Complication Probability(NTCP)Models in the Clinic.Int J Radiat Oncol Biol Phys.2010,7 6(30),S10-S19.
  • 5Hsin CH,Chen TH,Young YH,et al,2010.Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients.Otolaryngol Head Neck Surg..2010,143(5),662-668.
  • 6van der Putten L,de Bree R,Plukker JT,et al,2006.Permanent unilateral hearing loss after radiotherapy for parotid gland tumors.Head Neck..2006,28(10),902-908.
  • 7Adjan W,Hauser KF,Bakalkin G,et al,2007.Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin:differential effects on glia and neurons.Neuroscience.2007,148(3),724-736.(2015-2-27).
  • 8张明洁,刘业海,李慧,陈德尚,韩跃峰.鼻咽癌放疗后并发分泌性中耳炎的临床分析[J].中华耳科学杂志,2013,11(2):256-258. 被引量：15
  • 9艾有琴,赵青,陈金湘.早期干预在减缓鼻咽癌放疗后分泌性中耳炎中的作用[J].中华耳科学杂志,2014,12(4):677-679. 被引量：12

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现代肿瘤医学
2010年 第9期

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