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N-磷酰化二肽甲酯和金属离子的相互作用

Interaction of N-phosphoryl dipeptide methyl esters and metal ions
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摘要 用紫外光谱研究了合成的系列磷酰化肽酯(DPP)与几种不同价态的常见金属离子——K+、Ag+、Mg2+、Cu2+、Fe3+和Al3+的相互作用,讨论了不同结构的磷酰化肽酯与金属离子相互作用的规律.结果表明,系列磷酰化肽酯与6种金属离子的相互作用没有差别,均表现为与K+、Fe3+和Al3+几乎没有相互作用,与Mg2+和Cu2+有弱的相互作用,与Ag+有较强的相互作用.相互作用的结果使磷酰化肽酯在190 nm左右的吸收峰强度下降、最大吸收波长红移.主要的作用位点应是系列磷酰化肽酯分子中不饱和基团的杂原子.它们的相互作用主要受金属离子的离子半径、电荷数、电子构型、水解性能和浓度的影响. The interaction between a series of comparable N-diisopropyloxyphosphoryl（DIPP） dipeptides methyl esters（DPP） and several common metal ions（K＋,Ag＋,Mg2＋,Cu2＋,Fe3＋,Al3＋） was studied and compared with UV-vis spectrometer.The results showed that the five DPP had identical affinity for the metal ions.They all displayed little interaction with K＋,Fe3＋ and Al3＋,and showed weak interaction with Mg2＋ and Cu2＋.While they showed intensive interaction with Ag＋.The interaction made the absorption peak at 190 nm decrease and the maximum absorption wavelength lengthen.Therefore,the main binding site is the heteroatoms of unsaturated groups in DPP molecule.The different interaction between the six metal ions and DPP is resulted form their ionic radius,charge number,electron configuration,hydrolysis property and concentration.
作者 强黎明 刘若雨 曹书霞 卢奎
机构地区 河南工程学院材料与化学工程系 郑州大学化学系 南阳师范学院化学与制药工程学院
出处 《南阳师范学院学报》 CAS 2010年第9期34-37,共4页 Journal of Nanyang Normal University
基金 国家自然科学基金资助项目(20572016 20672104 20772023) 河南工程学院博士基金资助项目(D09004) 河南工程学院科技创新团队资助计划(2009IRTHNIE05)
关键词 N-磷酰化二肽甲酯 金属离子 非共价相互作用 紫外光谱 N-phosphoryl dipeptide methyl ester metal inos non-covalent interaction UV-vis spectra
分类号 O657.63 [理学—分析化学]
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参考文献13

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南阳师范学院学报
2010年 第9期

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