摘要
目的：本文对不同时间静滴大剂量氨甲蝶呤／醛氢叶酸解救治疗血液肿瘤患者的血药浓度进行监测及药效和毒性反应进行研究。方法：采用高效液相色谱法测定氨甲蝶呤的血药浓度，按不同时间静滴大剂量氨甲蝶呤将４１例病人分为两组；Ｓ组氨甲蝶呤于６ｈ滴完，Ｌ组于１２ｈ滴完，两组均在滴注完６ｈ开始醛氢叶酸救援。在滴注毕０．８、６、４２ｈ采血测定氨甲蝶呤血药浓度。结果：Ｓ组药物浓度在０．０８ｈ显著高于Ｌ组（Ｐ＜０．０１），６、１８、４２ｈ两组血药浓度无差异（Ｐ＞０．０１）。完全缓解率中位持续完全缓解及中位生存期两组间无显著差异（Ｐ＞０．０５），Ｌ组毒性反应明显比Ｓ组严重。结论：６ｈ滴完组的疗效比１２ｈ滴完组的好。
OBJECTIVES:The plasma levels were determined and the effect and toxic reaction were observed in leukemia patients who received high dose MTX/CF rescue therapy by IV drip in different allotted times.METHODS:The plasma levels of MTX were assayed by HPLC.Based on the duration of IV drip,41 patients were divided into 2 groups;groupS:Drug was dripped in 6 hour′s time,group L:in 12 hour′s time.Six hours after drip,CF rescue began to be given to both groups.Blood were sampled at 0.8,6,42h after drip for drug concentration determination.RESULTS:Drug level of groupS was higher than that of group L at 0.8h postdrip and there were no difference between 2 groups at 6,18,42h postdrip(P>0.01).There were no significant difference between 2 groups in complete remission rate,median persistent rate and median survival period (P>0.05).The toxic reaction was more severein group L.CONCLUSIONS:The therapeutic effect of group S was better than that of group L.
出处
《中国药房》
CAS
CSCD
1999年第3期129-130,共2页
China Pharmacy
关键词
氨甲蝶呤
醛氢叶酸
血液肿瘤
治疗
血药浓度
methotrexate/calcium folinate rescue therapy leukemia different drug administration scheme
