摘要
目的采用 Wistar 大鼠对颅骨(膜内成骨)和髂骨(软骨成骨)贴敷移植后早期再血管化进行了观察研究。方法用计算机图像处理进行定量分析。结果骨移植7天后,软骨成骨与膜内成骨血管密度分别为:22.33%和11.88%;14天时分别为34.93%和15.93%。结论软骨成骨移植后较膜内成骨有更加迅速的血管化。文中对骨移植后骨质结构,血管化以及骨质体积存留之间的关系进行了讨论。
Objective To investigate the disparity in early revascularization of the membranous and endochondral bone grafts.Methods Twenty Wistar rats were randomly divided into two groups of 10 each.Full-thickness cranial(membranous)and split-thickness iliac crest(endochondral)onlay bone grafts were placed subperiosteally onto the snout of the animal without bony fixation.At 7 and 14 days after grafting the bone grafts together with the recipient sites were harvested.Revascularization was studied uti- lizing opacifying injection and computerized image analysis technique.Results The extent of vasculariza- tion at 7 days was 11.88% and 22.33% in membranous and endochondral bone grafts,respectively,and they developed to be 15.93% and 34.93% at 14 days,respectively.Conclusion The results indicated that endochondral bone grafts were more rapidly revascularized than membranous bone grafts at 7 and 14 days(P<0.05).Differences in graft architecture are theorized to account for the relationship between the vascularization and volume maintenance in the bones of different embryonic origin.
