摘要
目的为提高对黏膜相关淋巴组织淋巴瘤（ＭＡＬＴ淋巴瘤）临床特征的认识。方法经我院确诊的ＭＡＬＴ淋巴瘤２４例，进行回顾性的临床分析研究。结果按原发部位可分为胃肠（ＧＩ）和非胃肠（ＮＯＮＧＩ）两组。ＧＩ组１８例（７５０％），ＮＯＮＧＩ组６例（２５０％），后者包括涎腺３例、肺２例和膀胱１例。手术治疗２１例，其中单用手术治疗１３例，术后合用化、放疗７例，合用放疗１例。单用化疗３例。随访１７例，失访７例，随访率为７０．８％。生存期４～１２１个月，平均３３个月，中位数１９个月。１７例随访病人中１６例已存活１～１０年，其中存活１年以上者占５８．８％、＞３年以上者占３５．３％、５年以上者占２９．４％、１０年以上者占５．９％。对临床分期和治疗措施与生存率比较显示差异无明显性（Ｐ＞０．０５）。结论ＭＡＬＴ淋巴瘤是非霍奇金淋巴瘤的一种独特亚型，具有起病隐匿、病程长、进展慢及患病率低、好发于中老年男性、Ｂ症状少见、易误诊为假性淋巴瘤、治疗疗效和预后良好等特征。
Objective To have a better understanding of the clinical characteristics of
mucosaassociated lymphoid tissue (MALT) lymphoma. Methods The clinical data of 24
patients with MALT lymphoma were analyzed . Results The patients were divided into two
groups according to the initial location of the lymphoma in the gastrointestinal(GI) tract or not.
Eighteen patients(75.0%) had GI involvement and six (25.0%) had involvement of other
extranodal sites including salivary gland in three, lung in two and bladder in one. Among the
24 cases, 12 were in stage, 7 in stage and 5 in stage at the time of pesentation. Fourteen
cases underwent endoscopic biopsy and the pathologic diagnoses were in accordance with
those of postoperative specimen in 11 but different in 3. Surgical resection was performed
alone in 21 patients, with adjuvant chemotherapy in 7 and with adjuvant radiotherapy in 1.
Three patients were treated with chemotherapy only. Results of survival analysis showed that
the overall survival rate was 58.8% after 1 year,35.3% after 3 years, 29.4% after 5 years and
5.9% after 10 years .No significant difference in clinical or biologic characteristics was
observed between GI and nonGI patients (P>0.05). The clinical stage and therapeutic measure
had no significant relation with the prognosis. Conclusion MALT lymphoma is an indolent
disease that presents in localized extranodal location without any associated adverse
prognostic factor in nearly all the patients and that these patients have a high reponse rate to
treatment and a long survival.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第5期320-322,共3页
Chinese Journal of Internal Medicine
关键词
非霍奇金
MALT
淋巴瘤
病理
Lymphoma, mucosaassociated lymphoid
tissueLymphoma, NonHodgkin's
