摘要
目的观察糖脉康颗粒治疗糖尿病周围神经病变(DPN)的临床疗效。方法将82例DPN患者随机分为对照组(40例)和治疗组(42例)。两组均给予糖尿病常规治疗,对照组另加用弥可保片,治疗组另加用糖脉康颗粒,两组疗程均为12周。观察治疗前后两组患者的肌电图及同型半胱氨酸(Hcy)、糖化血红蛋白(HbA1c)、脂质代谢的变化。结果治疗后治疗组患者的疗效显著优于对照组,有效率亦显著高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的正中神经及胫神经的运动、感觉传导速度及Hcy水平间差异无统计学意义(P>0.05);但治疗组治疗后HbA1c、三酰甘油(TC)、低密度脂蛋白胆固醇(LDL-C)水平较对照组显著下降,高密度脂蛋白胆固醇(HDL-C)水平较对照组显著升高,差异均有统计学意义(P<0.05)。治疗中,对照组有1例出现皮疹,2例出现胃肠道不适,而治疗组未见明显不良反应。结论糖脉康颗粒治疗DPN疗效优于甲钴胺,还可降低血脂和HbA1c水平,且不良反应少。
Objective To investigate the therapeutic effect of Tangmaikang on diabetic peripheral neuropathy （DPN）.Methods 82 patients with DPN were randomly divided into two groups.The control group （40 cases） was treated with conventional therapy and Methycobal tablets,and the treatment group （42 cases） was treated with Tangmaikang in addition to conventional therapy for 12 weeks.Observe the changes of electromyogram,homocysteinemia,glycosylated hemoglobin,lipid metabolism before and after treatment.Results Efficacy of treatment group is much better than that of control group,as well as the effective rate （P0.05）.The curative effect of motor nerve conduction velocity、sural nerve conduction velocity and homocysteic acid have no significant difference （P0.05） after treatment in two groups.Compared with control group,the glycosylated hemoglobin,TC and LDL-C all decreased obviously（P0.05）,HDL-C increased obviously（P0.05）after treatment in treatment group.In addition,breakout and gastrointestinal tract adverse effect was found in control group,but not in treatment group.Conclusion Tangmaikang is superior to mecobalamin in treating DPN,and it can also reduce blood fat level and HbA1c level,with few adverse effects.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第26期2996-2998,共3页
Chinese General Practice
关键词
糖尿病神经病变
糖脉康
甲钴胺
治疗结果
Diabetic neuropathies
Tangmaikang
Methycobal
Treatment outcome
