摘要
对１０例肾移植患者应用与未用更昔洛韦后环孢菌素Ａ的药动学参数及临床生化指标进行研究。采用荧光偏振免疫法测定血药浓度，３Ｐ８７程序拟合药动学参数。结果显示：应用更昔洛韦后，环孢菌素Ａ药动学参数Ｋｅ、ｔ１／２（Ｋａ）分别由未用组的（０．１６±０．０４）ｈ－１和（１．３９±０．７６）ｈ降至（０．０９±０．０５）ｈ－１和（０．５０±０．３２）ｈ（Ｐ＜０．０５），Ｔｍａｘ由（３．６７±０．７７）ｈ减至（２．００±０．７８）ｈ（Ｐ＜０．０１），ｔ１／２（Ｋｅ）由（４．０８±１．８５）ｈ增至（１０．５１±６．４２）ｈ（Ｐ＜０．０５），峰浓度Ｃｍａｘ平均升高２７％。肾移植后应用更昔洛韦组肾功指标下降，肝功指标上升，其中血清肌酐、总胆红质与未用组相比有统计学意义。表明更昔洛韦使肾移植患者环孢菌素Ａ的药动学参数及临床生化指标发生改变，提示临床调整用药方案。
To observe the effect of ganciclovir on pharmacokinetics parameters of cyclosporin A in kidney transplant patients.Pharmacokinetics parameters of cyclosporin A and clinical biochemistry indications were studied in 10 patients after single administration of cyclosporin A and after additional administration of ganciclovir respectively.Fluorescence polarization immunoassay method was applied for the determination of cyclosporin A in blood.And pharmacokinetics parameters were fitted with 3P87 program.After additional administration of ganciclovir, the Ke and T1/2(Ka)of cyclosporin A decreased from (0.160.04)h-1 and (1.390.76)h to (0.090.05)h-1and (0.500.32)h respectively (P<0.05).And the Tmaxwas reduced from (3670.77)h to (200078)h(P<0.01),The T1/2(Ke) increased from (4081.85)h to (10.516.42)h(P<0.05),The Cmax ascended by 27% .Levels of renal function were decreased while those of hepar function were increased.
出处
《西安医科大学学报》
CSCD
1999年第2期182-184,共3页
Journal of Xi'an Medical University(Chinese)
基金
陕西省科学技术研究发展计划项目
关键词
血药浓度
环孢菌素A
更昔洛韦
肾移植
pharmacokinetics parameters
clinical biochemistry indications
cyclosporin A
ganciclovir
kidney transplantation
