摘要
目的了解温州地区宫颈疾病妇女的人乳头状瘤病毒(HPV)感染现状,为对HPV防治提供流行病学数据。方法采用导流杂交基因分型技术(HybriMax)对2218例来自温州地区宫颈疾病患者宫颈脱落细胞标本进行HPV检测及基因分型,分析HPV在温州地区宫颈疾病妇女感染率以及高危型HPV(HR-HPV)感染率,研究不同HPV亚型在不同人群中分布等。结果宫颈疾病患者HPV感染率为60.05%,重叠感染率为26.10%,感染排名分别是HPV16、58、11、52、6,在≤24岁组及≥60岁组出现两次感染高峰;HR-HPV感染率为47.16%;HR-HPV亚型感染率排名分别是HPV16、58、52、33、31,以≥60岁组感染率为最高;宫颈炎症以HPV16、58、11为主,宫颈不典型增生以HPV16、52、58为主,宫颈癌以HPV16为主。结论 HPV在温州地区宫颈疾病妇女生殖道有较高的感染率及重叠感染率,不同宫颈疾病优势型别不同,故HPV感染应该引起社会的重视,加强常规检测HPV,以早期发现感染,及时干预。
OBJECTIVE To study the relationship of human papillomavirus（HPV） infection and disease of uterine cervix in women in Wenzhou City and analyze the key risk factors of high risk（HR）-HPV infection.METHODS A total of 2218 patients with disease of uterine cervix（including chronic cervicitis,cervical intraepithelial neoplasia,and cervical cancer） were investigated,and the cast-off cells samples of cervix uteri were collected.Meanwhile,the clinical data and laboratory result of these patients were gathered.The cast-off cells samples of cervix uteri were detected genotype of HPV with the flow-through hybridization technique（HybriMax）.RESULTS The cast-off cells samples of cervix uteri in 2218 cases were detected,and it showed 1332 patients were with HPV infection（60.05%）,consisting of 1046 patients infecting HR-HPV（47.16%） and 570 patients were infected with the superinfection of HPV（25.7%）.The typical infection spectra of HPV in women with the disease of uterine cervix（to decrease progressively） were HPV16,HPV58,HPV11,HPV52,HPV6,HPV33,HPV31,HPV18,HPV53,and HPV CP8304.The result showed that infection rate of HPV was high,especially,in the age groups≤24 and ≥60.The infection spectra of HR-HPV from the patients with disease of uterine cervix（to decrease progressively） were HPV16,HPV58,HPV52,HPV33,and HPV31 and the result showed that infection rate of HR-HPV was high,especially,in the age group≥60.The infection spectra of cervicitis were mostly HPV16,HPV58,and HPV11,that of cervix uteri were mainly HPV16,HPV52,and HPV58,and that of cancer of the cervix were principally HPV16.CONCLUSIONS The infection rate and superinfection rate of HPV from women with disease of uterine cervix in Wenzhou City are high,the infection rate of HR-HPV is higher than that of low risk（LR）-HPV.So the HPV infection should bring to society′s attention and enhance the conventional examination of HPV.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第19期2958-2960,共3页
Chinese Journal of Nosocomiology
