摘要
目的：用神经心理测验研究老年人轻度认知功能损害的特点。方法：为横断面比较研究。研究对象分为两组，即有轻度认知功能损害的老年人（ＭＣＩ组）和认知功能正常的老年人（对照组，ＮＣ组）。以世界卫生组织老年认知功能评价成套神经心理测验（ＷＨＯ－ＢＣＡＩ）为主要研究工具。结果：ＭＣＩ组２７例，ＮＣ组８３例。ＭＭＳＥ的平均总分ＭＣＩ组为２４．２±２．１分，ＮＣ组为２８．７±１．１分；ＡＤＬ的平均总分ＭＣＩ组为２４．９±１．８分，ＮＣ组为２１．４±１．３分。ＷＨＯ－ＢＣＡＩ测验结果显示，两组间听觉词汇学习测验中的６项，语言能力测验的３项，视觉测验的３项，２项连线测验，分类测验，精神运动测验和空间结构测验分别具有显著性差异。逐步判别分析入选判别方程的测验指标有连线测验Ｂ，小标记测验，精神运动测验，视觉推理和语义联系测验。结论：连线测验Ｂ、小标记测验、精神运动测验、视觉推理和语义联系测验能较好地区分ＭＣＩ和ＮＣ。
Objective: To
examine the characteristics of mild cognitive impairment of elderly subjects with
neuropsychological tests to enable early detection of Alzheimer disease. Method: 27 subjects
with mild cognitive impairment (MCI) and 33 normal controls (NC) were recruited. The World
Health Organisation battery of cognitive assessment instruments for elderly (WHOBCAI) was
adopted for cognitive assessment of the studied subjects. Results: The mean total scores of
minimental status examination (MMSE) were 24221 for MCI and 28711 for NC. The mean total
scores of activity of daily living (ADL) were 24918 for MCI and 21413 for NC. The results of
WHOBCAI tests demonstrated that there were significant differences between the two groups in
most of the subtests including auditory verbal learning, delayed recall, naming, verbal fluency,
sorting, minitoken, trail making, psychomotor testing, visual recognition, reasoning and
semantic association, and spatial construction. Among the significant variables, trail making B,
minitoken, psychomotor testing, visual reasoning and semantic association finally entered into
the standardized canonical discriminant functions. Conclusion: Our study suggest that trail
making B, minitoken, psychomotor testing, visual reasoning and semantic association can
discriminate MCI from normal controls and are thus sensitive tools in early detection of
Alzheimer disease.
出处
《临床精神医学杂志》
1999年第3期129-132,共4页
Journal of Clinical Psychiatry
基金
上海市卫生系统百人计划项目资助
关键词
认知功能损害
老年人
神经心理测验
Mild cognitive impairmentElderlyNeuropsychological test
