摘要
根据某些萜类化合物的抗癌构效关系，设计合成了１，２环戊二酮和１，２环己二酮Ｍａｎｎｉｃｈ碱衍生物．初步抗癌活性试验结果表明：１，２环戊二酮双Ｍａｎｎｉｃｈ碱抗癌活性较强，而１，２环戊二酮单Ｍａｎｎｉｃｈ碱及１。
The Mannich bases of 1,2cyclopentanedione and 1,2cyclohexandione,which had been designed on the basis of some terpinoids structure activity relationship,were synthesized and their anticancer activities on human tumor cell lines in vitro were tested.The results indicated that the bisMannich bases of 1,2cyclopentanedione had strong activity,but the monoMannich bases of 1,2cyclopentanedione and bisMannich bases of 1,2cyclohexanedione revealed low antitumor activity.
出处
《中国药物化学杂志》
CAS
CSCD
1999年第2期84-88,共5页
Chinese Journal of Medicinal Chemistry
关键词
环戊二酮
环己二酮
MANNICH碱
合成
抗癌活性
cyclopentandione
1,2cyclohexanedione
Mannich bases
synthesis
anticancer activities
