摘要
使用气固反应方法制备了[Ca24Al28O64]4+.4O-(C12A7-O-)粉末材料,运用X射线衍射(XRD)和电子自旋共振(ESR)对抗菌实验前后C12A7-O-材料结构特性的变化进行了表征,研究了C12A7-O-材料在溶液中对大肠杆菌E.Coli的抗菌性能.实验结果表明,C12A7-O-材料中含有的O-浓度约为2×1020/cm3.1mg/mL的C12A7-O-水溶液中,O-浓度约为4×1016/cm3.当菌液浓度为105cfu/mL时,1mg/mL的C12A7-O-水溶液可在1h内将大肠杆菌浓度降低99.98%.通过对比实验和分析发现,C12A7-O-粉末释放的O-离子是C12A7-O-溶液具有抗菌作用的重要因素之一.
The [Ca24Al28O64]4＋.4O-（C12A7-O-）particle was firstly investigated its antibacterial activity against bacteria E.Coli in aqueous solution and phosphate buffered saline（PBS）.The C12A7-O-particles were synthesized by gas-solid reaction method with CaCO3 and γ-Al2O3 in a molar ratio of 12：7.The structure change of the C12A7-O-particles was measured by X-ray diffraction（XRD）and electron spin resonance（ESR）after antibacterial test.The results show that the structure of the C12A7-O-particles is completely changed into the structure of（CaO）3Al2O3.6H2O and Al（OH）3.In the C12A7-O-solution（1 mg/mL）,the concentration of atomic oxygen anion（O-）in the solution is 4×1016 cm-3.In the antibacterial test with the particle concentration of 3 mg/mL in aqueous solution,the bacteria concentration in decreased by 99.98% in 1 h from the original concentration of 105 cfu/mL.When the particle concentration is 1 mg/mL in PBS,the pH is 7.4 and the pH effect of the solution could be neglected,but the bacteria concentration still deduces to 3.7×103 cfu/mL from the original concentration in 24 h.In briefly,O-is the main factor in the antibacterial test in the C12A7-O-PBS solution with the neutral pH environment.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第9期942-946,共5页
Journal of Inorganic Materials
基金
国家"863"项目(2009AA05Z435)
国家"973"项目(2007CB210206)
国家自然科学基金(50772107)~~
关键词
C12A7
抗菌性能
抗菌机理
C12A7
antibacterial activity
antibacterial mechanism
