摘要
目的探讨前颞海马杏仁核切除术式(CAH)对颞叶癫痫患者的精神症状的影响。方法 75例颞叶癫痫患者经历了CAH手术,并且3次(术前、术后1年、术后2年)顺利完成了SCL-90自评量表。统计分析患者的平均GSI(精神症状整体严重性)得分。结果患者术后1年和2年的平均GSI得分均低于术前。全体患者术后2年的平均GSI得分均低于术后1年。不同时期(术前、术后1年、术后2年)男女组之间,左右侧组之间以及头颅MRI正常和异常组之间的平均GSI得分均无显著性差异。结论 CAH术式可以改善颞叶癫痫患者术后的精神症状。这种改善与术后的疗效有关,而与性别、位置和MRI有无异常无关。
Object To study the association between Corticoamygdalohippocampectomy （CAH, anterior temporal lobe resection plus amygdalohippocampectomy） and the change of psychological in TLE patients. Methods Seventy-five medial TLE patients who had CAH accomplished SCL-90 （Symptom Check-list 90） questionnaires three times （pre-surgical, post-surgical and two years after surgery）. Average GSI （global severity index） scores in SCL-90 were calculated and statistically analyzed. Results The average GSI scores of the whole group 1 and 2 years after surgery was statistically lower than that of the pre-surgery. The average GSI score of the whole group 2 years after operation was statistically lower than that of 1 year after surgery. There were no statistical differences between （male/female, right/left, normal MRI/abnormal MRI） subgroups in different time points （pre-surgical, one and two years after surgery）. Conclusion CAH could improve the psychiatric symptoms of TLE patients as assessed by the SCL-90. This improvement is related to the therapeutic effect and is not associated with gender, location, and MRI abnormality.
出处
《北京医学》
CAS
2010年第10期782-784,共3页
Beijing Medical Journal
基金
国家自然科学基金(2005CB522800
2004CB318101)
首都医学发展科研基金(2009-3048)
