摘要
目的观察妊娠糖尿病(GDM)患者胰岛β细胞功能与脂联素、内脂素、瘦素、抵抗素等脂肪细胞因子的关系。方法入选GDM患者(GDM组,n=56)、正常妊娠妇女(妊娠组,n=60)和正常育龄妇女(对照组,n=50)为受试者,测定3组研究对象的血糖(FBG)、血脂、胰岛素(FINS)等生化指标和血脂联素、内脂素、瘦素和抵抗素的水平。用稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)和胰岛素敏感指数(ISI)评价胰岛β细胞功能。结果与对照组和妊娠组比较,GDM组患者的脂联素和内脂素水平下降,瘦素和抵抗素水平升高(P<0.05),同时FBG、FINS和HOMA-IR升高,HOMA-β和ISI下降(P<0.05)。Logistic回归分析显示,影响GDM患者胰岛β细胞功能的因素有年龄、孕期、体质量指数(BMI)、FBG、FINS、脂联素、内脂素、瘦素和抵抗素(P<0.05或0.01)。结论 GDM患者胰岛β细胞功能的受损可能与脂肪细胞因子分泌失衡有关。
Objective To study the relathionship between insulin,β cells funtion and related adipocyte factors（adiponectin,visfatin,leptin and resistin） in gestational diabetes mellitus patients.Methods Gestational diabetes mellitus patients（GDM group,n=56）,normal pregnant women（normal pregnant group,n=60） and healthy women（control group,n=50） were enrolled.Serum glucose,lipids,insulin,adiponectin,visfatin,leptin and resistin were measured among the three groups.Insulin resistance index（HOMA-IR）,insulin secretion index（HOMA-β） and insulin sensitivity index（ISI） were calculated.Results The levels of adiponectin and visfatin were decreased,leptin and resistin were increased in GDM group compared with those in normal pregnant group and control group（P0.05）,while FBG,FINS and HOMA-IR were greater,HOMA-β and ISI were lower in GDM group compared with those in normal pregnant group and control group（P0.05）.Logistic regression analysis showed that age,duration of pregnancy,BMI,FBG,FINS,adiponectin,visfatin,leptin,resistin and impaired insulin,β cells funtion of gestational diabetes mellitus patients had significant correlation（P0.05 or 0.01）.Conclusion Impaired insulin,β cells funtion of gestational diabetes mellitus patients may be related to secretion imbalance of adipocyte factors.
出处
《福建医科大学学报》
2010年第4期292-295,共4页
Journal of Fujian Medical University
关键词
糖尿病
妊娠
胰岛素
胰岛
瘦素
细胞因子类
激素类
异位
胰岛素抗药性
diabetes
gestational
insulin
islets of langerhans
leptin
cytokines
hormones
ectopic
insulin resistance
