摘要
目的:探讨颅脑外伤迟发颅内出血与凝血异常之间的关系。方法:303例颅脑外伤患者,分为迟发颅内出血组与非迟发颅内出血组,比较2组凝血指标,对颅脑外伤迟发颅内出血的可能危险因素做多因素分析,分析凝血指标异常程度对迟发颅内出血的预示作用。结果:303例中迟发颅内出血46例。迟发颅内出血组凝血酶时间、凝血酶原时间、活化部分凝血活酶时间、凝血酶原国际标准化比率均高于非迟发颅内出血组,血小板低于非迟发颅内出血组。多因素分析显示凝血异常是颅脑外伤迟发颅内出血的独立危险因素。凝血指标异常达2项时,出血率明显增高。结论:凝血异常是颅脑外伤迟发颅内出血的主要影响因素之一,异常指标达2项时易导致迟发颅内出血,适当补充凝血因子可有效防治颅脑外伤迟发颅内出血。
Objective To study the relationship between the delayed intracranial hemorrhage and coagulopathy in craniocerebral trauma.Methods A total of 303 cases of craniocerebral trauma were divided into delayed intracranial hemorrhage group（group A） and non-delayed intracranial hemorrhage group（group B）.The coagulation test results were compared between two groups.The risk factors for delayed intracranial hemorrhage were analyzed with multivariate analysis to study the predictive role of coagulopathy results in delayed intracranial hemorrhage.Results In 303 cases,46 suffered from delayed intracranial hemorrhage.The level of thrombin time,prothrombin time,activated partial thromboplastin time,international normalized ratio were higher and platelet was lower in group A than those in group B.Multivariate analysis showed that the coagulopathy was the independent risk factor for delayed intracranial hemorrhage in craniocerebral trauma.When there were two or more items of coagulopathy,the delayed intracranial hemorrhage rate was significantly higher.Conclusion Coagulopathy is one of the main risk factors for delayed intracranial hemorrhage in craniocerebral trauma.When there are two or more items of coagulopathy the delayed intracranial hemorrhage occurs easily.The complement of coagulation factors may effectively prevent the delayed intracranial hemorrhage in craniocerebral trauma.
出处
《中华实用诊断与治疗杂志》
2010年第10期971-973,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
颅脑外伤
迟发颅内出血
凝血异常
Craniocerebral trauma
delayed intracranial hemorrhage
coagulopathy
