摘要
目的探讨丙泊酚对罗哌卡因所致大鼠中枢及心脏毒性的影响。方法 30只雄性SD大鼠随机均分为3组(n=10),生理盐水组(A组)、丙泊酚Ⅰ组(B组)、丙泊酚Ⅱ组(C组)。实验前5min,A组大鼠股静脉注射生理盐水5ml/kg,B组大鼠股静脉注射0.5%丙泊酚5ml/kg,C组大鼠股静脉注射1%丙泊酚5ml/kg。所有实验动物股静脉置管泵注0.5%罗哌卡因,速度为2.5ml/(kg.min),并记录大鼠出现抽搐、心律失常和心跳停止的时间及罗哌卡因用量。结果 3组泵入罗哌卡因后均出现抽搐、室性心律失常及心跳停止的中枢及心脏毒性反应。B组、C组出现中枢及心脏毒性反应时的中毒剂量明显大于A组(P<0.01)。C组出现中枢及心脏毒性反应时的中毒剂量大于B组(P<0.01)。结论短时间内过量罗哌卡因引起大鼠的中枢及心脏毒性反应,预先给予丙泊酚可明显减轻罗哌卡因对大鼠的中枢及心脏毒性作用。
Objective To observe the effect of propofol on ropivacaine induced central nervous and cardiac toxicity in rats.Methods Thirty male SD rats were randomly divided into three groups.Five minutes before intravenous infusion of ropivacaine,the control group （group A） received infusion of 5 ml/kg saline,group B received infusion of 25 mg/kg （5 ml/kg） propofol and group C received infusion of 50 mg/kg （5 ml/kg） propofol.Then the femoral vein was cannulated for the infusion of 0.5% ropivacaine at a rate of 2.5 ml/（kg·min）.The time of convulsions,arrhythmia and asystole,and the corresponding doses of ropivacaine were recorded.Results The central nervous and cardiac toxicity reaction including convulsions,arrhythmia and asystole occurred in three groups.The doses of ropivacaine that induced central nervous and cardiac toxicity reaction were significantly larger in groups B and C than in group A （P0.01）.The doses of ropivacaine that induced central nervous and cardiac toxicity reaction were significantly larger in group C than in group B （P0.01）.Conclusion The infusion of over dose of ropivacaine in a short time will induce the central nervous and cardiac toxicity reaction.The propofol injection can reduce the toxicity of ropivacaine on the central nervous system and heart of rats.
出处
《华南国防医学杂志》
CAS
2010年第5期355-356,391,共3页
Military Medical Journal of South China
关键词
罗哌卡因
毒性
丙泊酚
Ropivacaine
Toxicity
Propofol
