摘要
目的探讨T淋巴细胞和血管内皮细胞在外阴白色病变的发生、发展及聚焦超声治疗中的作用。方法收集40例外阴皮肤标本(20例外阴白色病变为病变组,其中鳞状上皮增生型12例,硬化性苔藓型8例;20例经病理证实为正常外阴皮肤为对照组),病变组均经聚焦超声治疗,其中11例治疗后重取标本,均采用免疫组化法对标本中的T淋巴细胞和血管内皮细胞进行检测。结果病变组患者病损皮肤与对照组相比CD4+、CD8+T淋巴细胞减少,CD4/CD8比值减小,CD34+血管内皮细胞减少。经聚焦超声治疗后,CD4+、CD8+T淋巴细胞及CD34+血管内皮细胞增加。结论 T淋巴细胞和血管内皮细胞在外阴白色病变的发生、发展及聚焦超声治疗中发挥重要作用。
Objective To investigate the effect of T-lymphocyte and vascular endothelial cell in the occurrence and development of the vulval white lesion and the effect of focus ultrasonic treatment. Methods T-lymphocytes and vascular endothelial cells were detected in 40 vulval skin specimens（20 vulval white lesion cases,of which 12 cases were squamous hyperplasia,8 cases were lichen sclerosus;20 normal cases）by immunohistochemistry. All patients were treated by focus ultrasound,of which specimens were obtained from 11 cases again. Results CD4＋、CD8＋ T-lymphocytes,CD4/CD8,CD34＋vascular endothelial cells in patients had decreased than that in normal group. And the amount after focus ultrasonic treatment was obviously more than before. Conclusions T-lymphocytes and vascular endothelial cells play important roles in the occurrence, development of the vulval white lesion and focus ultrasonic treatment.
出处
《中华保健医学杂志》
2010年第5期364-366,共3页
Chinese Journal of Health Care and Medicine
基金
科技部中小企业创新基金(04C6225110422)
关键词
外阴白色病变
T淋巴细胞
血管内皮细胞
聚焦超声治疗
Vulval white lesions
T-lymphocyte
Vascular endothelial cell
Focus ultrasonic treatment
