摘要
目的对无症状性脑梗死患者的颈动脉粥样硬化、D-二聚体、同型半胱氨酸进行分析,探讨上述指标与无症状性脑梗死的关系。方法分别对无症状性脑梗死患者、有症状性脑梗死患者和正常人各50例行颈动脉彩色多普勒检查和D-二聚体、同型半胱氨酸检查。结果有症状性脑梗死组颈动脉粥样硬化、D-二聚体、同型半胱氨酸的水平均较无症状性脑梗死组明显升高(P<0.01)。两者与正常组比较差异均有统计学意义(P<0.01)。两者相关性分析示,无症状性脑梗死组的同型半胱氨酸与D-二聚体的相关系数为r=0.598、P<0.01;有症状性脑梗死组、正常组分别为r=0.605、P<0.01;r=0.631、P<0.01。同型半胱氨酸与D-二聚体在三组中不同斑块类型的表达情况示,各组间和组内差异均有统计学意义(P<0.01)。结论颈动脉粥样硬化与D-二聚体、同型半胱氨酸是无症状性脑梗死的高危因素;且不稳定斑块与D-二聚体、同型半胱氨酸关系密切;在脑梗死的发生过程中三者扮演了重要的角色。
Objective To analyse the changes of carotid atherosclerosis, D-dimer and homocysteine in pa- tients with asymptomatic cerebral infarction （ACI） and find the relationship of ACI with above indexes. Methods In 50 patients with ACI（ACI group）,50 patients with symptom cerebral infarction （CI group） and 50 normal people （normal group） the examination of carotid color Doppler ultrasound, D-dimer, and homocysteine were performed. Re- suits The levels of Carotid atherosclerosis, D-dimer and homocysteine in CI group was significantly higher than those in ACI group （P 〈0.01 ）. The levels of above indexes in ACI and CI groups were higher than those in the normal group （ P 〈 0. 01 ）. The correlation analysis showed, there was a positive correlation between homocysteine and D-dimer in ACI group （r = 0. 598, P 〈 0. 01 ） ; there was a positive correlation between homocysteine and D-dimer in CI group （ r = 0. 605, P 〈 0. 01 ） ; there was a positive correlation between homocysteine and D-dimer in normal group （r = 0. 631, P 〈 0. 01 ）. The examination results of homocysteine and D-dimer in different plaque types in three groups showed, there were statistically significant intragroup and intergroup differences （P 〈 0. 01 ）. Conclusion Carotid atherosclerosis, D-dimer and homocysteine are the risk factor for ACI; and unstable plaque is closely related with D-dimer and homocysteine; the three factors play an important role in the occurrence of cerebral infarction.
出处
《中国临床新医学》
2010年第10期959-962,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
