摘要
目的观察甘露醇和甘油果糖对颅脑损伤后颅内高压的治疗效果。方法 86例脑挫裂伤、脑内血肿所致颅内高压非手术病人随机分为甘露醇组(44例),甘油果糖组(42例)。在出现颅内高压症状后,甘露醇组应用20%甘露醇125ml静脉滴注每6～8h1次,连用5天后减量,疗程2周。甘油果糖组应用甘油果糖250ml静脉滴注每6～8h1次,连用5天后减量,疗程2周。治疗前及治疗后5天,2周分别进行头部CT扫描,观察颅内高压临床症状的缓解及脑内水肿范围情况。结果治疗后5天甘露醇组头痛明显缓解率明显优于甘油果糖组(P<0.01),水肿范围的消退也优于甘油果糖组(P<0.05)。治疗后2周两组临床症状的缓解及脑内水肿范围情况无显著性差异(P>0.05)。结论甘露醇与甘油果糖均能缓解颅脑损伤后颅内高压,减轻脑水肿。对于颅脑损伤后颅内高压水肿高峰期更适用甘露醇治疗。
Objective To observe the effects of glycerol fructose and mannitol in treating intracranial hypertension induced by craniocerebral injury. Methods Eighty - six patients with intracranial hypertension induced by contusion and laceration of brain and intracerebral hematoma were randomly divided into mannitol group （n =44） and glycerol fructose group（n =42）. After onset of symptoms of intracranial hypertension, 20% mannitol 125ml and glycerol fructose were administered to corresponding patients respectively by intravenous drip every 6 - 8h, tapered down over 5 days with a course of 2 weeks. Head CT scanning was performed before treatment,5 days and 2 weeks after treatment to observe the remission of clinical symptoms of intraeranial hypertension and the range change of cerebral edema. Results After 5 - day treatment, remission rate in mannitol group was significantly higher than that in glycerol fructose group （P 〈 0. 01 ） , and the same to edema range reduced （P 〈 0.05 ）. But after 2 - week treatment, these differences were of no statistical significance（P 〉 0.05）. Conclusion Both mannitol and glycerin fructose could relieve intracranial hypertension and alleviate cerebral edema. Mannitol was more appropriate in crest time of the disease.
出处
《医学研究杂志》
2010年第10期98-100,共3页
Journal of Medical Research
关键词
甘露醇
甘油果糖
颅脑损伤
颅内高压
Mannitol
Glycerol fructose
Craniocerebral injury
Intracranial hypertension
