摘要
培氟沙星（Pefloxacin）属第三代喹诺酮类药物,其化学结构是在诺氟沙星的哌嗪环对位氮原子上的氢被甲基取代而成.该药在体内分布广泛,在脑脊液中也有较高浓度,主要在肝脏代谢,通过肾和肝脏排泄,血浆半衰期长达10-13h（1）,主要用于革兰阴性菌和金葡球菌引起中度或重度感染.
Pefloxacin （Pefloxacin） is a third - generation quinolone, its chemical structure is in the piperazine ring of noriloxacin on the position of nitrogen atoms on the methyl hydrogen is replaced by made. Drug is widely distributed in the body in the cerebrospinal fluid has a higher concentration, mainly in the liver and excreted through the kidneys and liver, plasma half- life of up to 10 - 13h （ 1 ）. Mainly for Gram -negative bacteria and Staphylococcus aureus caused by the degree or severe infection.
出处
《中外医学研究》
2010年第24期188-189,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
培氟沙星
氟诺酮类
不良反应
防治措施
Pefloxacin
Fluoride promise ketones
Adverse reactions
Preventive measures
