摘要
目的观察紫杉醇与铂类联合化疗对卵巢上皮性癌的近期疗效及毒副反应。方法选择新疆医科大学附属肿瘤医院2004年1月～2006年12月住院治疗的卵巢癌患者,满足研究条件的卵巢上皮性癌患者53例,经满意的肿瘤细胞减灭术后,初治患者给予TP一线化疗,复发患者铂类敏感者给予TP二线化疗。采用TP方案化疗:紫杉醇135～175mg/m2(第1天),顺铂60～80mg/m2或卡铂(AUC)(曲线下面积)5.0(第2天),全身静脉化疗,21～28d为1个疗程,至少完成4个疗程观察疗效。结果一线化疗中早期卵巢癌有效率为100.00%(7/7),晚期有效率为82.61%(19/23)。二化治疗中早期卵巢癌有效率为80.00%(4/5),晚期有效率为61.15%(11/18)。毒副反应主要为Ⅱ～Ⅲ度骨髓抑制,发生率为73.58%(39/53),Ⅳ度骨髓抑制发生率为3.77%(2/53)。胃肠道反应发生率64.2%(34/53),所有患者均未因毒副作用中断或退出治疗。结论 TP方案联合化疗在卵巢上皮癌的治疗中有效率高,毒副反应轻,患者易于接受。
Objective To study the recently curative effect and side effect in combined chemotherapy of paclitaxel and platinum in Epithelial Ovarian Carcinomas （EOCs）.Methods The patients,choosed from affiliated hospital,were treated from January 2004 to December 2006.There are 53 EOCs cases satisfied to our standards.After the cytoreductive surgery,the patients have been treated with TP as first line chemotherapy,the patients have been recurred using TP as second line chemotherapy.The TP chemotherapy plan is as following,that paclitaxel 135~175 mg/m2 （d 1） or docetaxel 75 mg/m2 （d 1） and platinum 60~80 mg/m2 or carboplatin um （AUC）： 5.0 （d 2） or oxaliplatin 130 mg/m2 （d 2） iv,21~28 day is one cycle,completed 4 cycles at least,then to observe the curative effect.Results In the first line treatment,the efficiency ratio is 100%（7/7） in early-stage and middle stage,and 82.61% （19/23） in advanced patients.In the second line treatment,the efficiency ratio is 80% （4/5） in early-stage and middle stage,and 61.15%（11/18） in advanced patients.The side effect mainly showed up in Ⅱ～Ⅲ arrest of bone marrow,the ratio is 73.58%（39/53）.The ratio of Ⅳ arrest of bone marrow is 3.77%（2/53）,the gastrointestinal reaction ratio is 64.2%（34/53）.All the patients did not break up or quit the treatments.Conclusion The efficiency ratio of combined chemotherapy of TP plan is 60%,and the plan has light side effect which could be easily accepted by the patients.
出处
《新疆医科大学学报》
CAS
2010年第8期964-966,共3页
Journal of Xinjiang Medical University
关键词
卵巢上皮性癌
紫杉醇
顺铂
化疗
epithelial ovarian carcinomas（EOCs）
chemotherapy
paclitaxel
platinum
clinical effects
