摘要
目的观察依达拉奉治疗急性脑梗死（ACI）的疗效。方法采用随机对照试验,选择发病24h的急性脑梗死患者58例,随机分为治疗组（28例）,对照组（30例）。对照组给予常规治疗,阿斯匹林,血栓通注射液,有脑水肿的给予20%甘露醇脱水,减轻脑水肿。治疗组在常规治疗的基础上加用依达拉奉30mg,每日2次,静脉滴注,疗程为2周（14d）。治疗前和治疗后3周（21d）对患者进行神经功能缺损评定及疗效评定。结果治疗组总显效率64.30%,对照组总显效率36.7%,两组比较检验有统计学意义（P〈0.05）。21d后两组神经缺损评定变化值比较检验有统计学意义（P〈0.05）,两组无不良反应。结论依达拉奉能有效改善急性脑梗死的神经功能缺损,治疗急性脑梗死患者疗效好,安全性高。
Objective To observe the edaravone treatment of acute cerebral infarction （ACI） efficacy. Methods A randomized controlled trial, select a 24-hour incidence of 58 cases of acute cerebral infarction were randomly divided into treatment group （28 cases）, the control group （30 cases）. Control group was given conventional treatment, aspirin, Xueshuantong injection, there is cerebral edema in 20% mannitol for dehydration, to reduce cerebral edema. The treatment group on the basis of conventional therapy of edaravone was added 30mg, 2 times a day, intravenous drip treatment for 2 weeks （14 days）. Treatment before and 3 weeks after treatment （21 days） in patients with neurological impairment assessment and efficacy assessed. Results In the treatment group was markedly effective rate was 64.30% in the control group was markedly effective rate 36.7%, test the two groups was statistically significant （p 〈0.05）. 21 days later, two groups of nerve defect inspection and assessment of changes in the value of comparison was statistically significant （p 〈0.05）, the two groups without adverse reaction. Conclusion Edaravone can effectively improve the neurologic impairment of acute cerebral infarction, the treatment of acute cerebral infarction in patients with good efficacy, high safety.
作者
王幼萌
WANG You-meng （Fuyang City People＇s Hospital,Fuyang 236004,China）
出处
《医学信息》
2010年第22期4197-4198,共2页
Journal of Medical Information
关键词
依达拉奉
自由基
脑梗死
edaravone
free radical
cerebral infarction
